期刊
HYPERTENSION RESEARCH
卷 45, 期 4, 页码 665-674出版社
SPRINGERNATURE
DOI: 10.1038/s41440-021-00805-z
关键词
Blood pressure; Sodium; Advanced glycation end products; Kidney tubules; Lithium
资金
- National Natural Science Foundation of China [81970353, 82070432, 82070435, 81770455, 91639203, 81400312, 81470533]
- Ministry of Science and Technology, Beijing, China [2016YFC0900902, 2016YFC1300100, 2018YFC1704902]
- Shanghai Commissions of Science and Technology [19ZR1443300, 19YF1441000, 15XD1503200, 14ZR1436200]
- Shanghai Municipal Health Commission [201940297, 20204Y0001, 2017BR025, 15GWZK0802]
- Three-year Action Program of Shanghai Municipality for Strengthening the Construction of Public Health System Big Data and Artificial Intelligence Application, Shanghai, China [GWV-10.1-XK05]
AGEs may lead to hypertension by enhancing proximal sodium handling and on low dietary sodium intake.
Advanced glycation end product (AGE) clearance may cause renal tubular injuries, such as changes in sodium reabsorption. We hypothesize that AGEs interact with sodium metabolism to influence blood pressure (BP). The study participants were outpatients who were suspected of having hypertension but had not been treated with antihypertensive medication. Clinic and ambulatory blood pressures were measured at baseline (n = 989) and during follow-up (median, 4.4 years, n = 293). Plasma AGE concentrations were measured by enzyme-linked immunosorbent assay. Twenty-four-hour urine was collected for measurements of creatinine, sodium and lithium. In a cross-sectional analysis (n = 989), subjects in the top quintile versus quintiles 1-4 of plasma AGE concentration had significantly (P <= 0.004) lower fractional excretion of lithium (18.3% vs. 21.6%) and fractional distal reabsorption rate of sodium (95.0% vs. 95.8%) but similar BP (P >= 0.25). However, there was an interaction between plasma AGE concentration and urinary sodium excretion in relation to diastolic BP (P <= 0.058). Only in participants with low urinary sodium chloride excretion (<= 6 grams/day, n = 189), clinic (84.3 vs. 80.2 mmHg), 24-h (83.9 vs. 80.4 mmHg), daytime (87.8 vs. 84.8 mmHg) and nighttime (75.1 vs. 72.1 mmHg) diastolic BP at baseline were higher (P <= 0.05) in the top quintile than in quintiles 1-4 of plasma AGE concentration. In the longitudinal study (n = 383), similar trends were observed, with significant (P <= 0.05) differences in the increment in daytime diastolic BP (6.8 vs. -1.7 mmHg) and incidence of ambulatory and treated hypertension (hazard ratio 3.73) during follow-up. In conclusion, AGEs were associated with high BP, probably via enhanced proximal sodium handling and on low dietary sodium intake.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据