期刊
HUMAN BRAIN MAPPING
卷 43, 期 7, 页码 2249-2261出版社
WILEY
DOI: 10.1002/hbm.25785
关键词
functional connectivity; infants; neurodevelopment; prematurity; resting-state fMRI; sensorimotor cortex; somatotopic organization
资金
- Chalmers Life Science Engineering Area of Advance
- H2020 Future and Emerging Technologies, NIMA [899626]
- H2020 Industrial Leadership, CONBOTS [871803]
- H2020 Marie Sklodowska-Curie Actions, INFANTPATTERNS [846679]
- MR Transition Support Award [MR/V036874/1]
- MRC Clinician Scientist Fellowship [MR/P008712/1]
- NIHR Comprehensive Biomedical Research Centre Award
- Wellcome Engineering and Physical Sciences Research Council (EPSRC) Centre for Medical Engineering [WT 203148/Z/16/Z]
- ERC Grant [319456]
- European Research Council under the European Union's Seventh Framework Programme [FP/2007-2013]
- Marie Curie Actions (MSCA) [846679] Funding Source: Marie Curie Actions (MSCA)
Study shows that functional connectivity between limb regions in the sensorimotor cortex is already present in preterm infants, and it strengthens with age until reaching an adult-like configuration. These changes are specific to the sensorimotor network and are more dependent on age rather than age of birth.
In the mature human brain, the neural processing related to different body parts is reflected in patterns of functional connectivity, which is strongest between functional homologs in opposite cortical hemispheres. To understand how this organization is first established, we investigated functional connectivity between limb regions in the sensorimotor cortex in 400 preterm and term infants aged across the equivalent period to the third trimester of gestation (32-45 weeks postmenstrual age). Masks were obtained from empirically derived functional responses in neonates from an independent data set. We demonstrate the early presence of a crude but spatially organized functional connectivity, that rapidly matures across the preterm period to achieve an adult-like configuration by the normal time of birth. Specifically, connectivity was strongest between homolog regions, followed by connectivity between adjacent regions (different limbs but same hemisphere) already in the preterm brain, and increased with age. These changes were specific to the sensorimotor network. Crucially, these trajectories were strongly dependent on age more than age of birth. This demonstrates that during the perinatal period the sensorimotor cortex undergoes preprogrammed changes determining the functional movement organization that are not altered by preterm birth in absence of brain injury.
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