期刊
HUMAN BRAIN MAPPING
卷 43, 期 5, 页码 1710-1719出版社
WILEY
DOI: 10.1002/hbm.25752
关键词
amplitude of low frequency fluctuations; amyotrophic lateral sclerosis; functional connectivity; resting state fMRI; slow and fast progression rates
资金
- Beijing Hospitals Authority Youth Program [QML20190803]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20180802]
- Capital Health Development Research Project [2018-4-2015]
- National Natural Science Foundation of China [81801255, 82001352]
The study found that the local activity and network functional connectivity in the PSMA region can explain disease severity differently in fast and slow progression groups of ALS patients.
The huge heterogeneity of the disease progression rate may cause inconsistent findings between local activity and functional connectivity of the primary sensorimotor area (PSMA) in amyotrophic lateral sclerosis (ALS). For illustration of this hypothesis, resting-state fMRI (RS-fMRI) data were collected and analyzed on 38 definite or probable ALS patients (19 fast and 19 slow, cut off median = 0.41) and 37 matched healthy controls. Amplitude of low frequency fluctuations (ALFFs) and functional connectivity strength (FCS) were analyzed within the PSMA. There was a decreased ALFF (p(FDR) <.05) and FCS (p = .022) in all ALS patients. The two metrics shared about 50% of variance (R = .7) and both showed significant positive correlation with ALS Functional Rating Scale-Revised (ALSFRS-R) in the fast (p values <.034) but not in the slow progression groups. Interestingly, when regressing out the ALFF, the PSMA network FCS, especially the inter-hemisphere FCS, showed negative correlation with the ALSFRS-R score in the slow (R = -.54, p = .026) but not the fast progression group. In summary, the current results suggest that RS-fMRI local activity and network functional connectivity accounts for the severity differently in the slow and fast progression ALS patients.
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