期刊
HORMONES AND BEHAVIOR
卷 136, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yhbeh.2021.105081
关键词
Lordosis; Oxytocin; PGE2; GnRH
资金
- Fondo Sectorial de investigacion para la Educacion del CONACYT [CB-255936/2015]
The study investigated the involvement of the Oxytocin/Prostaglandin E2/GnRH pathway in the facilitation of lordosis behavior induced by OT in rats. Results showed that blocking OT receptor, COX2, EP4 prostaglandin receptor, or GnRH-1 receptor inhibited OT-induced lordosis behavior, suggesting a direct involvement of hypothalamic astrocytes.
Intracerebroventricular (icv) administration of oxytocin (OT) induces robust lordosis behavior (lordosis quotient and lordosis intensity) in estrogen-primed rats. The present study explored the hypothesis that the OTProstaglandin E2-GnRH pathway (a pathway produced in astrocytes) is involved in the facilitation of lordosis behavior by icv infusion of OT (2 mu g). In Experiment 1, we tested the involvement of the OT receptor (OTR) by infusion of the OTR antagonist, atosiban (ATO). OT-induced lordosis was significantly reduced at both 30 and 120 min by prior infusion of ATO. In Experiment 2, we studied the effects of aspirin (COX2 inhibitor) and ONOAE3-208 (ONO; EP4 prostaglandin receptor antagonist) on OT-induced lordosis. Infusions of both compounds diminished OT-induced lordosis at both 120 and 240 min. In Experiment 3, the involvement of the GnRH-1 receptor inhibitor antide on OT-induced lordosis was evaluated. Antide significantly inhibited OT-induced lordosis at all times tested. These data indicate that the OT/PGE2/GnRH pathway is involved in the expression of OT-induced lordosis behavior, an effect that may be occurring directly in hypothalamic astrocytes.
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