4.6 Review

Pathology updates and diagnostic approaches to haemophagocytic lymphohistiocytosis

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Review Pediatrics

Genetics and pathophysiology of haemophagocytic lymphohistiocytosis

Marie Meeths et al.

Summary: HLH is a life-threatening hyperinflammatory syndrome with genetic predisposition and associations with variants in genes related to metabolism or immunity. Molecular insights have provided fundamental knowledge of the immune system, deepening our understanding of hyperinflammatory diseases and highlighting new treatment strategies.

ACTA PAEDIATRICA (2021)

Article Medicine, General & Internal

Haemophagocytic lymphohistiocytosis secondary to brucellosis in a young child

Jashan Mittal et al.

Summary: Brucellosis is a common worldwide zoonotic disease with protean clinical manifestations that can sometimes be life-threatening. This case study highlights a 4-year-old boy who showed complete clinical and biochemical improvement after 6 weeks of treatment. Hemophagocytic lymphohistiocytosis (HLH) should be suspected in children with brucellosis who do not respond to antibiotic treatment, and secondary HLH may improve with adequate treatment of the underlying condition.

BMJ CASE REPORTS (2021)

Review Hematology

Pediatric hemophagocytic lymphohistiocytosis

Scott W. Canna et al.

Article Medicine, General & Internal

Could hemophagocytic lymphohistiocytosis be the core issue of severe COVID-19 cases?

Violetta Opoka-Winiarska et al.

BMC MEDICINE (2020)

Letter Hematology

Secondary HLH is uncommon in severe COVID-19

Henry Wood et al.

BRITISH JOURNAL OF HAEMATOLOGY (2020)

Article Medicine, General & Internal

Hemophagocytic Lymphohistiocytosis in a Patient With Advanced HIV and Cytomegalovirus Infection

Amir Anabtawi et al.

JOURNAL OF INVESTIGATIVE MEDICINE HIGH IMPACT CASE REPORTS (2020)

Review Clinical Neurology

A Review of Neuropathological Features of Familial and Adult Hemophagocytic Lymphohistiocytosis

Colleen Klein et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2019)

Article Medicine, General & Internal

A rare case of hepatosplenic gamma-delta T-cell lymphoma and secondary hemophagocytic lymphohistiocytosis

Philip H. Brandt et al.

CLINICAL CASE REPORTS (2019)

Review Immunology

The Immunology of Macrophage Activation Syndrome

Courtney B. Crayne et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Pathology

Hemophagocytic Lymphohistiocytosis

Hanny Al-Samkari et al.

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 13 (2018)

Review Immunology

Epstein-Barr Virus and Hemophagocytic Lymphohistiocytosis

Rebecca A. Marsh

FRONTIERS IN IMMUNOLOGY (2018)

Article Immunology

How Viruses Contribute to the Pathogenesis of Hemophagocytic Lymphohistiocytosis

Ellen Brisse et al.

FRONTIERS IN IMMUNOLOGY (2017)

Article Dermatology

Role of Skin Biopsies in the Diagnosis of Hemophagocytic Lymphohistiocytosis

Aileen Santos-Arroyo et al.

AMERICAN JOURNAL OF DERMATOPATHOLOGY (2017)

Article Hematology

Malignancy-associated haemophagocytic lymphohistiocytosis in children and adolescents

Kai Lehmberg et al.

BRITISH JOURNAL OF HAEMATOLOGY (2015)

Article Medicine, General & Internal

Secondary haemophagocytic lymphohistiocytosis: Experience from the Uppsala University Hospital

Torbjorn Karlsson

UPSALA JOURNAL OF MEDICAL SCIENCES (2015)

Review Immunology

Histoplasmosis-Induced Hemophagocytic Syndrome: A Case Series and Review of the Literature

Jennifer Leigh Townsend et al.

OPEN FORUM INFECTIOUS DISEASES (2015)

Article Medicine, General & Internal

Adult haemophagocytic syndrome

Manuel Ramos-Casals et al.

LANCET (2014)

Review Hematology

Hemophagocytic lymphohistiocytosis: review of etiologies and management

Melissa R. George

JOURNAL OF BLOOD MEDICINE (2014)

Article Oncology

Leishmania in HLH: A Rare Finding With Significant Treatment Implications

Gurpreet Singh et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2013)

Article Pathology

Flow Cytometric Findings in Hemophagocytic Lymphohistiocytosis

Chad M. McCall et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2012)

Article Pathology

Prevalence and Clinical Significance of Kupffer Cell Hyperplasia With Hemophagocytosis in Liver Biopsies

Virginie Prendki et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2011)

Review Immunology

SLAM Family Receptors and SAP Adaptors in Immunity

Jennifer L. Cannons et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 29 (2011)

Article Pathology

Pathology of the Liver in Familial Hemophagocytic Lymphohistiocytosis

Jey-Hsin Chen et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2010)

Review Infectious Diseases

Haemophagocytic syndrome and HIV

Tomas Doyle et al.

CURRENT OPINION IN INFECTIOUS DISEASES (2009)

Article Oncology

Experience With Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome at a Single Institution

Abha A. Gupta et al.

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY (2009)

Article Oncology

Atypical Varicella Zoster Infection Associated With Hemophagocytic Lymphohistiocytosis

Jutte E. van der Werff ten Bosch et al.

PEDIATRIC BLOOD & CANCER (2009)

Article Infectious Diseases

Infections associated with haemophagocytic syndrome

Nadine G. Rouphael et al.

LANCET INFECTIOUS DISEASES (2007)

Review Oncology

HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis

Jan-Inge Henter et al.

PEDIATRIC BLOOD & CANCER (2007)

Article Multidisciplinary Sciences

XIAP deficiency in humans causes an X-linked lymphoproliferative syndrome

Stephaine Rigaud et al.

NATURE (2006)

Article Infectious Diseases

Tuberculosis-associated haemophagocytic syndrome

Priscilla K. Brastianos et al.

LANCET INFECTIOUS DISEASES (2006)

Article Immunology

Patient data, early SARS epidemic, Taiwan

PR Hsueh et al.

EMERGING INFECTIOUS DISEASES (2004)

Review Rheumatology

Reactive hemophagocytic syndrome in adult systemic disease: Report of twenty-six cases and literature review

R Dhote et al.

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH (2003)

Article Dermatology

Cutaneous manifestations of hemophagocytic lymphohistiocytosis

DS Morrell et al.

ARCHIVES OF DERMATOLOGY (2002)

Article Immunology

Tuberculosis-associated hemophagocytic syndrome in an infant

PH Shaw et al.

PEDIATRIC INFECTIOUS DISEASE JOURNAL (2000)