期刊
HISTOPATHOLOGY
卷 80, 期 4, 页码 720-728出版社
WILEY
DOI: 10.1111/his.14580
关键词
Epstein-Barr virus; immunohistochemistry; lymphoepithelioma-like cholangiocarcinoma; lymphoepithelioma-like lesion; molecular
资金
- Hong Kong Research Grants Council Theme-based Research Scheme [T12-704/16-R]
- Innovation and Technology Commission grant for State Key Laboratory of Liver Research
- National Research Foundation of Korea (NRF) - Korean Government (MSIT) [NRF-2020R1A2B5B01001646, NRF-2016M3A9D5A01952416]
This study presented three rare cases of intrahepatic biliary EBV-associated LEL tumors, with a distinctly benign biliary epithelial component, low proliferation index, and good prognosis. These cases with unique features warrant further investigation and may require revision of the current nomenclature.
Aims Lymphoepithelioma-like carcinomas (LELCs) are uncommon epithelial cancers characteristically showing two distinct components consisting of malignant epithelial cells and prominent dense lymphoid infiltrate. Hepatic LELCs consist of two types, the lymphoepithelioma-like hepatocellular carcinoma and lymphoepithelioma-like cholangiocarcinoma (LEL-CCA), with the latter being strongly associated with Epstein-Barr virus (EBV). Methods and results We present a series of three cases of intrahepatic biliary EBV-associated LEL tumours in which the biliary epithelial component showed a distinctly benign appearance, instead of the usual malignant epithelial features of a typical CCA or EBV-associated LEL-CCA. In the lesions, the biliary epithelium showed interconnecting glands or cords of cells. All had a very low proliferation (Ki-67) index. Immunohistochemistry for IDH1 and TP53 performed on two cases was negative and molecular tests for EGFR and KRAS gene mutations performed on one were negative. Prognosis was very good in all three cases, with patients alive with no evidence of disease 24-62 months after surgery. Intriguingly, all three cases had co-infection of HBV and EBV. These cases are also discussed in the context of the 63 cases of LEL-CCA available in the literature, with a focus on epidemiology, clinicopathological features and potential research interests. Conclusions Based on the distinct clinicopathological features and unique survival benefits, we believe these tumours represent the benign end of the spectrum of EBV-associated lymphoepithelial biliary carcinomas. Whether these tumours require a revision of the current nomenclature to 'lymphoepithelioma-like neoplasm of the biliary tract with probable low malignant potential' will require more detailed analysis with larger case-series.
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