☆ 4.8 Article

Disrupted BRCA1-PALB2 interaction induces tumor immunosuppression and T-lymphocyte infiltration in HCC through cGAS-STING pathway

HEPATOLOGY (2023)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Oncology

MLH1 Deficiency-Triggered DNA Hyperexcision by Exonuclease 1 Activates the cGAS-STING Pathway

Junhong Guan et al.

Summary: This study revealed that loss of MutLa subunit MLH1 leads to production of neoantigens and activation of the cGAS-STING pathway, affecting DNA repair process and ultimately causing chromosomal abnormalities and DNA release. This unknown MMR mechanism has significant implications for genome stability and cancer therapy.

CANCER CELL (2021)

添加到收藏夹

Review Biochemistry & Molecular Biology

Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment

Khiem C. Lam et al.

Summary: This study reveals how the microbiota influences the immune components of the TME to improve cancer therapy. Modulating the microbiota can trigger the IFN-I-NK cell-DC axis within tumors, enhancing the efficacy of immune checkpoint blockade (ICB).

CELL (2021)

添加到收藏夹

Article Medicine, General & Internal

Hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, particularly hepatocellular carcinoma (HCC), poses a significant global health challenge with rising incidence projected to exceed 1 million cases by 2025. Infection by hepatitis B and C viruses remains a major risk factor for HCC, while non-alcoholic steatohepatitis is emerging as a more common risk factor in Western countries. Advances in systemic therapies for HCC, including immunotherapies and targeted therapies, are expected to revolutionize the management of this disease.

NATURE REVIEWS DISEASE PRIMERS (2021)

添加到收藏夹

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

添加到收藏夹

Review Oncology

Immunotherapy Updates in Advanced Hepatocellular Carcinoma

Amisha Singh et al.

Summary: Immunotherapy has the potential to improve outcomes in advanced HCC by overcoming immune tolerance mechanisms and enhancing anti-tumor activity in the tumor microenvironment. Ongoing clinical trials may offer additional frontline treatment options for HCC. Preliminary data on CAR-T cell therapy for HCC treatment also shows promise for the future.

CANCERS (2021)

添加到收藏夹

Review Oncology

New insights into M1/M2 macrophages: key modulators in cancer progression

Jiuyang Liu et al.

Summary: This article examines the critical roles of M1 and M2 macrophages in tumor progression, with M1 possessing anti-tumor properties and M2 promoting tumor growth and metastasis.

CANCER CELL INTERNATIONAL (2021)

添加到收藏夹

Article Multidisciplinary Sciences

BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage

Zhihua Kang et al.

Summary: BRCA2 is recruited to the replication fork through interaction with MCM10 to inhibit repriming and single-strand DNA gap formation after DNA damage. BRCA2-deficient cells exhibit radio-resistant DNA synthesis phenotype following DNA damage.

NATURE COMMUNICATIONS (2021)

添加到收藏夹

Review Oncology

PALB2 Variants: Protein Domains and Cancer Susceptibility

Thales C. Nepomuceno et al.

Summary: The loss-of-function variants of PALB2 mentioned in the study are typically located in the coiled coil (CC) or WD40 domains, which highlights the importance of these modular domains in the DNA damage response (DDR) and tumor suppression.

TRENDS IN CANCER (2021)

添加到收藏夹

Article Oncology

Replication Gaps Underlie BRCA Deficiency and Therapy Response

Nicholas J. Panzarino et al.

Summary: The sensitivity of BRCA-deficient cancers is attributed to the presence of ssDNA replication gaps, rather than defects in homologous recombination or fork protection. The restoration of fork restraint or gap filling can confer therapy resistance, while restored FP and HR do not necessarily contribute to therapy resistance in the presence of gaps. Additionally, the study suggests that DNA double-strand breaks are induced from cell death nucleases and are not fundamental to the mechanism of action of genotoxic agents.

CANCER RESEARCH (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

The cGAS-STING pathway is a therapeutic target in a preclinical model of hepatocellular carcinoma

Martin K. Thomsen et al.

ONCOGENE (2020)

添加到收藏夹

Article Oncology

Pembrolizumab As Second-Line Therapy in Patients With Advanced Hepatocellular Carcinoma in KEYNOTE-240: A Randomized, Double-Blind, Phase III Trial

Richard S. Finn et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

添加到收藏夹

Review Oncology

The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer

John Kwon et al.

CANCER DISCOVERY (2020)

添加到收藏夹

Review Biochemistry & Molecular Biology

Comprehensive elaboration of the cGAS-STING signaling axis in cancer development and immunotherapy

Juyan Zheng et al.

MOLECULAR CANCER (2020)

添加到收藏夹

Review Oncology

Trial watch: STING agonists in cancer therapy

Julie Le Naour et al.

ONCOIMMUNOLOGY (2020)

添加到收藏夹

Article Gastroenterology & Hepatology

The BRUCE-ATR Signaling Axis Is Required for Accurate DNA Replication and Suppression of Liver Cancer Development

Chunmin Ge et al.

HEPATOLOGY (2019)

添加到收藏夹

Article Biochemistry & Molecular Biology

Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma

Qiang Gao et al.

CELL (2019)

添加到收藏夹

Review Biochemistry & Molecular Biology

ROS and the DNA damage response in cancer

Upadhyayula Sai Srinivas et al.

REDOX BIOLOGY (2019)

添加到收藏夹

Article Oncology

Evidence of Intertissue Differences in the DNA Damage Response and the Pro-oncogenic Role of NF-κB in Mice with Disengaged BRCA1-PALB2 Interaction

Amar Hekmat Mahdi et al.

CANCER RESEARCH (2018)

添加到收藏夹

Review Immunology

Immune checkpoint blockade therapy for cancer: An overview of FDA-approved immune checkpoint inhibitors

Kristian M. Hargadon et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

添加到收藏夹

Review Immunology

The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer

Tuo Li et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

添加到收藏夹

Review Oncology

Mechanisms of Oncogene-Induced Replication Stress: Jigsaw Falling into Place

Panagiotis Kotsantis et al.

CANCER DISCOVERY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Oxidative DNA damage induced by ROS-modulating agents with the ability to target DNA: A comparison of the biological characteristics of citrus pectin and apple pectin

Fahimeh Salehi et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Review Biochemistry & Molecular Biology

Impact of germline and somatic BRCA1/2 mutations: tumor spectrum and detection platforms

H. Wu et al.

GENE THERAPY (2017)

添加到收藏夹

Editorial Material Medicine, General & Internal

Immune oncology in hepatocellular carcinoma-hype and hope

Marcus-Alexander Woerns et al.

LANCET (2017)

添加到收藏夹

Article Medicine, General & Internal

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

Anthony B. El-Khoueiry et al.

LANCET (2017)

添加到收藏夹

Article Oncology

TIMER: A Web Server for Comprehensive Analysis of Tumor-Infiltrating Immune Cells

Taiwen Li et al.

CANCER RESEARCH (2017)

添加到收藏夹

Review Oncology

Combination cancer immunotherapies tailored to the tumour microenvironment

Mark J. Smyth et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

添加到收藏夹

Article Gastroenterology & Hepatology

Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

Martin K. Thomsen et al.

HEPATOLOGY (2016)

添加到收藏夹

Article Cell Biology

Genome-Derived Cytosolic DNA Mediates Type I Interferon-Dependent Rejection of B Cell Lymphoma Cells

Yu J. Shen et al.

Cell Reports (2015)

添加到收藏夹

Article Oncology

STAT1 Drives Tumor Progression in Serous Papillary Endometrial Cancer

Budiman Kharma et al.

CANCER RESEARCH (2014)

添加到收藏夹

Article Biochemistry & Molecular Biology

Male Fertility Defect Associated with Disrupted BRCA1-PALB2 Interaction in Mice

Srilatha Simhadri et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

添加到收藏夹

Article Gastroenterology & Hepatology

The Degree of Liver Injury Determines the Role of p21 in Liver Regeneration and Hepatocarcinogenesis in Mice

Laura Elisa Buitrago-Molina et al.

HEPATOLOGY (2013)

添加到收藏夹

Article Multidisciplinary Sciences

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun et al.

SCIENCE (2013)

添加到收藏夹

Article Biochemistry & Molecular Biology

PALB2 Links BRCA1 and BRCA2 in the DNA-Damage Response

Feng Zhang et al.

CURRENT BIOLOGY (2009)

添加到收藏夹

Article Multidisciplinary Sciences

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

Shirley M. H. Sy et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

添加到收藏夹

Article Biochemistry & Molecular Biology

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2

Bing Xia et al.

MOLECULAR CELL (2006)

添加到收藏夹

Review Cell Biology

BRCA1 gene in breast cancer

EM Rosen et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2003)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.