期刊
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
卷 44, 期 4, 页码 876-888出版社
WILEY
DOI: 10.1002/hed.26983
关键词
in-field failure; intensity-modulated radiotherapy; nasopharyngeal carcinoma; radioresistance; tumor factors
资金
- National Natural Science Foundation of China [82003241, 82073354]
This study aims to identify tumor factors associated with in-field failure in patients with nasopharyngeal carcinoma (NPC) receiving intensity-modulated radiotherapy (IMRT). The results showed that in-field failure was the major pattern of recurrence in NPC patients. Large tumor volume, nonkeratinizing differentiated carcinoma, and cervical nodal necrosis were independent tumor factors associated with in-field failure.
Background To identify the tumor factors of in-field failure for nasopharyngeal carcinoma (NPC) in the intensity-modulated radiotherapy (IMRT) era. Methods Patterns of recurrence were classified as in-field, marginal, and out-field failures. Multivariate analyses with the Cox proportional hazards model were used to identify tumor-related factors of in-field failure. Results A total of 1039 patients with NPC received IMRT from 2012 to 2019 and 75 developed recurrences, with 88.0% (66/75) considered as having in-field failures. Multivariate analysis showed that pretreatment gross tumor volume of nasopharynx >= 68.8 mL and histopathological type of nonkeratinizing differentiated carcinoma (NKDC) were the independent tumor factors of in-field local failure, while gross tumor volume of involved lymph nodes >= 19.9 mL and cervical nodal necrosis (CNN) were associated with in-field regional failure (all p < 0.05). Conclusions In-field failure was the major pattern of recurrence in patients with NPC. Large tumor volume, NKDC, and CNN were the tumor factors associated with in-field failure.
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