期刊
GREEN CHEMISTRY
卷 24, 期 3, 页码 1103-1108出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1gc04109f
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资金
- Natural Science Foundation of Shaanxi Province [2021JQ-018]
- Fundamental Research Funds for the Central Universities [xzy032020008]
- Xi'an Jiaotong University (XJTU) [YX6J006]
A new visible light-mediated protocol for polychlorination of alkenes has been reported using commercially available bulk chemicals, chloroform and chlorides. This method allows the introduction of multiple chlorine atoms into alkenes in a single step, providing the corresponding chloroalkanes in high yields under mild reaction conditions. Furthermore, this transformation exhibits broad substrate scope, tolerating substituted olefins, chlorides, and pharmaceutical-derived olefins. Preliminary mechanism studies suggest the involvement of a radical-polar crossover mechanism as the primary pathway.
We report a novel visible light-mediated protocol for polychlorination of alkenes by employing commercially available bulk chemicals, chloroform and chlorides. This methodology enables the installation of multiple chlorine atoms into alkene feedstocks in a single step and provides the corresponding chloroalkanes in high yields under mild reaction conditions. Additionally, this transformation tolerates a broad substrate scope of substituted olefins, chlorides and pharmaceutical-derived olefins. Initial mechanism studies suggest that a radical-polar crossover mechanism is primarily involved.
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