期刊
GLIA
卷 70, 期 6, 页码 1009-1026出版社
WILEY
DOI: 10.1002/glia.24145
关键词
astrocyte; clearance; microglia; phagocyte; phagocytic receptor; phagocytosis; synapse
资金
- Japan Agency for Medical Research and Development [JP21gm1310008]
- Japan Science and Technology Agency [JPMJCR14G2]
- Japan Society for the Promotion of Science [19H03395, 19H04746, 19K06904, 20H05060, 20H05902, 21H04786, 21K19309]
- Mitsubishi Foundation
- Nakatomi Foundation
- Takeda Science Foundation
- Yamanashi Brain-Immune Research Center
- Grants-in-Aid for Scientific Research [19H03395, 19H04746, 20H05060, 20H05902, 21H04786, 21K19309, 19K06904] Funding Source: KAKEN
This study discusses the role and consequences of astrocytic phagocytosis, focusing on its differences from microglial phagocytosis and how these two phagocytic systems cooperate.
Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or for recovery after injury. Live cells or parts thereof, such as the synapses and myelin, are appropriately eliminated by phagocytosis to maintain or refine neural networks during development and adulthood. Microglia, the specific population of resident macrophages in the CNS, are classically considered as primary phagocytes; however, astrocytes have also been highlighted as phagocytes in the last decade. Phagocytic targets and receptors are reported to be mostly common between astrocytes and microglia, which raises the question of how astrocytic phagocytosis differs from microglial phagocytosis, and how these two phagocytic systems cooperate. In this review, we address the consequences of astrocytic phagocytosis, particularly focusing on these elusive points.
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