期刊
GENE
卷 810, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.gene.2021.146067
关键词
Genetics; Next generation sequencing; Sudden cardiac death; Sudden non-cardiac death; Panel sequencing
资金
- Department of Cardiology of Shanghai Ninth People's Hospital
Sudden death in young adults can result from genetic and environmental factors, requiring an understanding of genetic etiology for prevention. The causes of sudden death are complex and varied, with genetic risk factors playing a significant role.
Sudden death is one of the major causes of death in young adults. Sudden death could be a result from both genetic and environmental or acquired factors. Understanding the genetic etiology is crucial to prevent preventable sudden death for those who are not aware of their genetic condition. In fact, the spectrum of causes of sudden death is complex and varied. In this study, we reviewed the genes that are associated with multiple causes of sudden death in terms of both sudden cardiac death and sudden noncardiac death. A summary of genetic risk factors of the major causes of genetic relevant sudden death is also provided. We believe this review could benefit the researchers who are interested in sudden death genetic studies or the young people who are concerning about their own risk on sudden death.
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