期刊
FUTURE MICROBIOLOGY
卷 16, 期 15, 页码 1161-1166出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0091
关键词
children; epidemiology; immunocompromised; Iran; Tropheryma whipplei
类别
资金
- Pasteur Institute of Iran
- Qom University of Medical Sciences [96855]
- Italian Ministry of Health 'Fondi Ricerca Corrente -Project L3P1'
The study found that 10% of children with immunodeficiency in central Iran carry the T. whipplei bacterium. Acute lymphocytic leukemia was the most common immunodeficient disease among them.
Aim & method: Tropheryma whipplei causes Whipple's disease. Children are reservoirs of this bacterium. The aim of this study was to investigate the presence of T. whipplei in children with immunodeficiency in central Iran from July 2018 to February 2019. Stool samples were tested by SYBR Green and Taq-Man real-time PCR assays. For confirmation, the isolated DNA was sequenced. Results: One hundred and thirty children were enrolled. Acute lymphocytic leukemia was the most reported immunodeficient disease (77%), followed by non-Hodgkin lymphoma and retinoblastoma. Thirteen (10%) children had T. whipplei DNA in the stool; 11.4% of the children under 5 years old were positive. Conclusion: This is the first study showing the circulation of T. whipplei in Iran.
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