期刊
FUTURE MICROBIOLOGY
卷 17, 期 5, 页码 363-375出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2021-0206
关键词
adhesion; Bacteroides; biofilm; Clostridioides difficile; prebiotics
类别
资金
- National Science Centre in Cracow, Poland [UMO: 2017/25/N/NZ6/01763]
- Medical University of Warsaw
The study aimed to determine the effect of standard and candidate prebiotics on the adhesion and biofilm formation of Bacteroides sp. The results showed that prebiotics and synbiotics may help decrease the burden of C. difficile infections.
Aim: The objective of this study was to determine the effect of standard and candidate prebiotics on the adhesion and biofilm formation of Bacteroides sp. in monoculture and co-culture with Clostridioides difficile. Materials & methods: The effect of seven prebiotics on the adhesion and biofilm formation of Bacteroides sp. to three human cell lines was determined. The effect of Bacteroides sp. and fructooligosaccharides (FOS) on the adhesion and biofilm formation of C. difficile was tested by the co-incubation assay. Results: Inulin, mannose and raffinose presented the best anti-adhesion properties against Bacteroides sp. Combination of Bacteroides sp. with FOS decreased the adhesion of C. difficile. Conclusion: The study shows the potential role of prebiotics and synbiotics in decreasing the burden of C. difficile infections.
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