4.5 Editorial Material

Proteolysis-targeting chimeras: a kaleidoscope of targeted protein degradation

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Chemistry, Multidisciplinary

RNA-PROTACs: Degraders of RNA-Binding Proteins

Alice Ghidini et al.

Summary: RNA-PROTACs represent a novel approach for targeting RBPs by using small RNA mimics to induce proteasomal degradation, potentially holding promise for applications in cancer cells.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

Article Pharmacology & Pharmacy

Homo-PROTAC mediated suicide of MDM2 to treat non-small cell lung cancer

Shipeng He et al.

Summary: The novel homo-PROTAC strategy induces self-degradation of MDM2, showing efficient disruption of MDM2-P53 interaction in non-small cell lung cancer cells. In in vivo studies, the homo-PROTAC exhibits potent antitumor activity targeting A549 xenografts, demonstrating its potential as a safe therapy for cancer treatment.

ACTA PHARMACEUTICA SINICA B (2021)

Article Chemistry, Multidisciplinary

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Jing Liu et al.

Summary: A new therapeutic platform TF-PROTAC has been developed with selectivity to degrade target TFs and demonstrate anti-proliferative effects in cells. This platform holds promise as a universal strategy for targeting undruggable TFs.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2021)

Review Oncology

Advancing targeted protein degradation for cancer therapy

Brandon Dale et al.

Summary: The development of small-molecule degraders such as proteolysis-targeting chimeras (PROTACs) has enabled the targeting of previously considered undruggable oncoproteins. This review discusses recent advances in the field, with a focus on opportunities and challenges for future development.

NATURE REVIEWS CANCER (2021)

Article Multidisciplinary Sciences

PHOTACs enable optical control of protein degradation

Martin Reynders et al.

SCIENCE ADVANCES (2020)

Article Chemistry, Medicinal

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Yu-Hui Jin et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Multidisciplinary Sciences

Multispecific drugs herald a new era of biopharmaceutical innovation

Raymond J. Deshaies

NATURE (2020)

Review Biochemistry & Molecular Biology

PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics

Sajid Khan et al.

ONCOGENE (2020)

Article Chemistry, Medicinal

On the Promise of Photopharmacology Using Photoswitches: A Medicinal Chemist's Perspective

Matthew J. Fuchter

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Multidisciplinary

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Roy Weinstain et al.

CHEMICAL REVIEWS (2020)

Review Biochemistry & Molecular Biology

PROTACs: An Emerging Therapeutic Modality in Precision Medicine

Dhanusha A. Nalawansha et al.

CELL CHEMICAL BIOLOGY (2020)

Article Chemistry, Multidisciplinary

Reversible Spatiotemporal Control of Induced Protein Degradation by Bistable PhotoPROTACs

Patrick Pfaff et al.

ACS CENTRAL SCIENCE (2019)

Article Multidisciplinary Sciences

Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

Blake E. Smith et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML

Matthias Brand et al.

CELL CHEMICAL BIOLOGY (2019)

Article Chemistry, Medicinal

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

Mengchen Lu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Biotechnology & Applied Microbiology

Induced protein degradation: an emerging drug discovery paradigm

Ashton C. Lai et al.

NATURE REVIEWS DRUG DISCOVERY (2017)

Article Biochemistry & Molecular Biology

Structural basis of PROTAC cooperative recognition for selective protein degradation

Morgan S. Gadd et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Multidisciplinary Sciences

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Chiara Maniaci et al.

NATURE COMMUNICATIONS (2017)

Article Biochemistry & Molecular Biology

Specific Knockdown of Endogenous Tau Protein by Peptide-Directed Ubiquitin-Proteasome Degradation

Ting-Ting Chu et al.

CELL CHEMICAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation

KM Sakamoto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)