期刊
FRONTIERS IN NEUROENDOCRINOLOGY
卷 63, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yfrne.2021.100947
关键词
Endocrine; neuroendocrine; Cellular excitability; Background sodium conductance; Hormone secretion; Resting membrane potential; Stimulus-secretion coupling; Anterior pituitary; Pancreas; Adrenal gland
资金
- Centre National de la Recherche Scientifique, Institut National de la Sante et de la Recherche Medicale
- Laboratory of Excellence Ion Channel Science and Therapeutics (LabEx ICST) [ANR-11-LABX-0015-01]
- Fondation pour la Recherche Medicale [DEQ20170336728]
The study focuses on the impact of background Na+ currents on cellular excitability and hormone secretion in endocrine/neuroendocrine tissues. Data collected and analyzed, as well as modeling, shed light on the functional involvement of INab in cells.
In endocrine/neuroendocrine tissues, excitability of secretory cells is patterned by the repertoire of ion channels and there is clear evidence that extracellular sodium (Na+) ions contribute to hormone secretion. While voltagegated channels involved in action potential generation are well-described, the background 'leak' channels operating near the resting membrane potential are much less known, and in particular the channels supporting a background entry of Na+ ions. These background Na+ currents (called here 'INab') have the ability to modulate the resting membrane potential and subsequently affect action potential firing. Here we compile and analyze the data collected from three endocrine/neuroendocrine tissues: the anterior pituitary gland, the adrenal medulla and the endocrine pancreas. We also model how INab can be functionally involved in cellular excitability. Finally, towards deciphering the physiological role of INab in endocrine/neuroendocrine cells, its implication in hormone release is also discussed.
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