4.6 Review

Advancing reproductive neuroendocrinology through research on the regulation of GnIH and on its diverse actions on reproductive physiology and behavior

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RFamide-Related Peptide Neurons Modulate Reproductive Function and Stress Responses

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Summary: RFRP neurons play a crucial role in regulating fertility and stress responses, with their activation delaying puberty onset and reproductive cycle progression, while ablation or silencing may attenuate or eliminate stress-induced reproductive suppression. Furthermore, RFRP neuronal activation stimulates glucocorticoid secretion, indicating a feedback loop linking stress and reproductive axes.

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Acute social defeat stress upregulates gonadotrophin inhibitory hormone and its receptor but not corticotropin-releasing hormone and ACTH in the Male Nile Tilapia (Oreochromis niloticus)

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Summary: The study found that acute social defeat stress in male Nile tilapia increases the synthesis of GnIH in the brain but does not change the expression levels of CRH and ACTH. This could lead to temporary reproductive dysfunction in the tilapia.

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RFRP3 increases food intake in a sex-dependent manner in the seasonal hamster Phodopus sungorus

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RFRP-3, the Mammalian Ortholog of GnIH, Is a Novel Modulator Involved in Food Intake and Glucose Homeostasis

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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Kisspeptin and RFRP3 modulate body mass in Phodopus sungorus via two different neuroendocrine pathways

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JOURNAL OF NEUROENDOCRINOLOGY (2019)

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Functional Implications of RFRP-3 in the Central Control of Daily and Seasonal Rhythms in Reproduction

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FRONTIERS IN ENDOCRINOLOGY (2019)

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Effects of high and low temperature on expression of GnIH, GnIH receptor, GH and PRL genes in the male grass puffer during breeding season

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GENERAL AND COMPARATIVE ENDOCRINOLOGY (2019)

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Discovery of GnIH and Its Role in Hypothyroidism-Induced Delayed Puberty

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ENDOCRINOLOGY (2018)

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Direct effects of RFRP-1, a mammalian GnIH ortholog, on ovarian activities of the cyclic mouse

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GENERAL AND COMPARATIVE ENDOCRINOLOGY (2017)

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Noradrenergic modulation of gonadotrophin-inhibitory hormone gene expression in the brain of Japanese quail

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JOURNAL OF NEUROENDOCRINOLOGY (2017)

Article Biochemistry & Molecular Biology

Interaction of melatonin and gonadotropin-inhibitory hormone on the zebrafish brain-pituitary-reproductive axis

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Involvement of gonadotropin-inhibitory hormone in pubertal disorders induced by thyroid status

Mika Kiyohara et al.

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Article Biochemistry & Molecular Biology

Effect of cortisol on gonadotropin inhibitory hormone (GnIH) in the cinnamon clownfish, Amphiprion melanopus

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No Evidence That RFamide-Related Peptide 3 Directly Modulates LH Secretion in the Ewe

C. Decourt et al.

ENDOCRINOLOGY (2016)

Article Endocrinology & Metabolism

Molecular, cellular, morphological, physiological and behavioral aspects of gonadotropin-inhibitory hormone

Takayoshi Ubuka et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2016)

Article Endocrinology & Metabolism

GnIH Control of Feeding and Reproductive Behaviors

Kazuyoshi Tsutsui et al.

FRONTIERS IN ENDOCRINOLOGY (2016)

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The role of RFamide-related peptide 3 (RFRP3) in regulation of the neuroendocrine reproductive and growth axes of the boar

Jennifer F. Thorson et al.

ANIMAL REPRODUCTION SCIENCE (2015)

Article Endocrinology & Metabolism

Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression

Keisuke Ikegami et al.

ENDOCRINOLOGY (2015)

Review Endocrinology & Metabolism

Seasonal control of gonadotropin-inhibitory hormone (GnIH) in birds and mammals

Lance J. Kriegsfeld et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

An Evolutionary Scenario for Gonadotrophin-Inhibitory Hormone in Chordates

T. Osugi et al.

JOURNAL OF NEUROENDOCRINOLOGY (2015)

Article Genetics & Heredity

Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status

Julia Jaroslawska et al.

PLOS GENETICS (2015)

Review Endocrinology & Metabolism

Contribution of GnIH Research to the Progress of Reproductive Neuroendocrinology

Kazuyoshi Tsutsui et al.

FRONTIERS IN ENDOCRINOLOGY (2015)

Article Endocrinology & Metabolism

Inhibitory roles of the mammalian GnIH ortholog RFRP3 in testicular activities in adult mice

Shabana Anjum et al.

JOURNAL OF ENDOCRINOLOGY (2014)

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Hypothalamic inhibition of socio-sexual behaviour by increasing neuroestrogen synthesis

Takayoshi Ubuka et al.

NATURE COMMUNICATIONS (2014)

Review Endocrinology & Metabolism

Central and direct regulation of testicular activity by gonadotropin-inhibitory hormone and its receptor

Takayoshi Ubuka et al.

FRONTIERS IN ENDOCRINOLOGY (2014)

Review Endocrinology & Metabolism

Gonadotropin-inhibitory hormone (GnIH), GnIH receptor and cell signaling

Takayoshi Ubuka et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2013)

Review Behavioral Sciences

When do we eat? Ingestive behavior, survival, and reproductive success

Jill E. Schneider et al.

HORMONES AND BEHAVIOR (2013)

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Distribution and Seasonal Variation in Hypothalamic RF-amide Peptides in a Semi-Desert Rodent, the Jerboa

A. Janati et al.

JOURNAL OF NEUROENDOCRINOLOGY (2013)

Article Cell Biology

Evidences for the regulation of GnRH and GTH expression by GnIH in the goldfish, Carassius auratus

Xin Qi et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2013)

Review Neurosciences

Kisspeptins and RFRP-3 act in concert to synchronize rodent reproduction with seasons

Valerie Simonneaux et al.

FRONTIERS IN NEUROSCIENCE (2013)

Article Biology

Melatonin delays clutch initiation in a wild songbird

Timothy J. Greives et al.

BIOLOGY LETTERS (2012)

Article Endocrinology & Metabolism

Gonadotropin-Inhibitory Hormone (GnIH) Secretion into the Ovine Hypophyseal Portal System

Jeremy T. Smith et al.

ENDOCRINOLOGY (2012)

Review Endocrinology & Metabolism

Rapid control of male typical behaviors by brain-derived estrogens

Charlotte A. Cornil et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2012)

Review Endocrinology & Metabolism

Gonadotropin-inhibitory hormone (GnIH): Discovery, progress and prospect

Kazuyoshi Tsutsui et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2012)

Article Cell Biology

Seasonal effect of GnIH on gonadotrope functions in the pituitary of goldfish

M. Moussavi et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2012)

Article Multidisciplinary Sciences

RNA Interference of Gonadotropin-Inhibitory Hormone Gene Induces Arousal in Songbirds

Takayoshi Ubuka et al.

PLOS ONE (2012)

Article Endocrinology & Metabolism

Human and Quail Aromatase Activity Is Rapidly and Reversibly Inhibited by Phosphorylating Conditions

Thierry D. Charlier et al.

ENDOCRINOLOGY (2011)

Article Endocrinology & Metabolism

Effects of Melatonin on Peripheral Reproductive Function: Regulation of Testicular GnIH and Testosterone

Nicolette L. McGuire et al.

ENDOCRINOLOGY (2011)

Article Obstetrics & Gynecology

Effects of gonadotropin-inhibitory hormone on folliculogenesis and steroidogenesis of cyclic mice

Padmasana Singh et al.

FERTILITY AND STERILITY (2011)

Review Endocrinology & Metabolism

Stress and reproduction: Controversies and challenges

Dhan Chand et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2011)

Article Behavioral Sciences

Social and breeding status are associated with the expression of GnIH

R. M. Calisi et al.

GENES BRAIN AND BEHAVIOR (2011)

Article Immunology

Thyroid hormone receptors and reproduction

Ralf Dittrich et al.

JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2011)

Article Endocrinology & Metabolism

Sex Differences in Brain Aromatase Activity: Genomic and Non-Genomic Controls

Jacques Balthazart et al.

Frontiers in Endocrinology (2011)

Article Endocrinology & Metabolism

Melatonin Stimulates the Release of Gonadotropin-Inhibitory Hormone by the Avian Hypothalamus

Vishwajit S. Chowdhury et al.

ENDOCRINOLOGY (2010)

Review Endocrinology & Metabolism

Gonadotropin-inhibitory hormone (GnIH) and its control of central and peripheral reproductive function

Kazuyoshi Tsutsui et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2010)

Review Endocrinology & Metabolism

Neurosteroid biosynthesis: Enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides

Jean Luc Do Rego et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2009)

Article Endocrinology & Metabolism

Are rapid changes in gonadal testosterone release involved in the fast modulation of brain estrogen effects?

Charlotte A. Cornil et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2009)

Article Neurosciences

Gonadotropin-Inhibitory Hormone Identification, cDNA Cloning, and Distribution in Rhesus Macaque Brain

Takayoshi Ubuka et al.

JOURNAL OF COMPARATIVE NEUROLOGY (2009)

Article Zoology

Estradiol, a Key Endocrine Signal in the Sexual Differentiation and Activation of Reproductive Behavior in Quail

Jacques Balthazart et al.

JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY (2009)

Article Multidisciplinary Sciences

Stress increases putative gonadotropin inhibitory hormone and decreases luteinizing hormone in male rats

Elizabeth D. Kirby et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Biochemistry & Molecular Biology

The orexigenic effect of GnIH is mediated by central opioid receptors in chicks

Tetsuya Tachibana et al.

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY (2008)

Article Endocrinology & Metabolism

RFamide-related peptide gene is a melatonin-driven photoperiodic gene

Florent G. Revel et al.

ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

Changes in GnRH I, bradykinin and their receptors and GnIH in the ovary of Calotes versicolor during reproductive cycle

Padmasana Singh et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

Gonadotropin-inhibitory hormone and its receptor in the avian reproductive system

George E. Bentley et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

Hypophysiotropic role of RFamide-related peptide-3 in the inhibition of LH secretion in female rats

Masahiro Murakami et al.

JOURNAL OF ENDOCRINOLOGY (2008)

Article Endocrinology & Metabolism

The general and comparative biology of gonadotropin-inhibitory hormone (GnIH)

Kazuyoshi Tsutsui et al.

GENERAL AND COMPARATIVE ENDOCRINOLOGY (2007)

Article Behavioral Sciences

Rapid inhibition of female sexual behavior by gonadotropin-inhibitory hormone (GnIH)

GE Bentley et al.

HORMONES AND BEHAVIOR (2006)

Article Multidisciplinary Sciences

Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals

LJ Kriegsfeld et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Multidisciplinary Sciences

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

F Simonin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Endocrinology & Metabolism

Rapid control of brain aromatase activity by glutamatergic inputs

J Balthazart et al.

ENDOCRINOLOGY (2006)

Article Neurosciences

Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

T Tachibana et al.

BRAIN RESEARCH (2005)

Article Multidisciplinary Sciences

Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain

T Ubuka et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Cell Biology

Distribution of a novel avian gonadotropin-inhibitory hormone in the quail brain

K Ukena et al.

CELL AND TISSUE RESEARCH (2003)

Article Neurosciences

Calcium-dependent phosphorylation processes control brain aromatase in quail

J Balthazart et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2003)

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Phosphorylation processes mediate rapid changes of brain aromatase activity

J Balthazart et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2001)

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FMRFamide in the amphibian brain: A comprehensive survey

RK Rastogi et al.

MICROSCOPY RESEARCH AND TECHNIQUE (2001)

Article Biochemistry & Molecular Biology

A novel avian hypothalamic peptide inhibiting gonadotropin release

K Tsutsui et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)