Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

Article Clinical Neurology

Bidirectional and state-dependent modulation of brain activity by transcranial focused ultrasound in non-human primates

Pai-Feng Yang et al.

Summary: Transcranial focused ultrasound stimulation under MRI guidance can modulate neural activity bidirectionally, while also evaluating causal interactions between functional circuits.

BRAIN STIMULATION (2021)

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Article Neurosciences

Influence of behavioral state on the neuromodulatory effect of low-intensity transcranial ultrasound stimulation on hippocampal CA1 in mouse

Xingran Wang et al.

Summary: The study found that neural activity induced by ultrasound stimulation in mice is modulated by the behavioral state, with significant differences in neural activity and response under different behavioral states. Additionally, the intensity of ultrasound also has a linear impact on neural activity, showing potential benefits for the application of ultrasound stimulation in neuroscience.

NEUROIMAGE (2021)

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Article Acoustics

TRANSCRANIAL FOCUSED ULTRASOUND ENHANCES SENSORY DISCRIMINATION CAPABILITY THROUGH SOMATOSENSORY CORTICAL EXCITATION

Chang Liu et al.

Summary: This study investigated the neural mechanism underlying ultrasound-mediated somatosensory enhancement by conducting tactile vibration frequency discrimination tasks while applying tFUS onto the primary somatosensory cortex. The results showed that tFUS was able to improve sensory discrimination capability through excitatory effects at the targeted sensory cortex, as revealed by EEG and ESI analysis.

ULTRASOUND IN MEDICINE AND BIOLOGY (2021)

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Article Clinical Neurology

Deep brain stimulation and electromagnetic interference

Shervin Rahimpour et al.

Summary: Deep brain stimulation is an approved and effective treatment for certain disorders, but external electromagnetic interference can cause device malfunction or damage, and there is a lack of comprehensive studies and guidelines on these issues.

CLINICAL NEUROLOGY AND NEUROSURGERY (2021)

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Review Behavioral Sciences

Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Yue Wang et al.

Summary: With the development of medical technology, vagus nerve stimulation (VNS) has been approved by the FDA as an alternative treatment for refractory epilepsy, refractory depression, cluster headaches, and migraines. Although VNS has shown promising results for more brain diseases like Parkinson's disease, autistic spectrum disorder, and traumatic brain injury, the specific biological mechanisms underlying its beneficial effects remain incompletely understood.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2021)

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Article Neurosciences

Low-Intensity Focused Ultrasound-Mediated Attenuation of Acute Seizure Activity Based on EEG Brain Functional Connectivity

Minjian Zhang et al.

Summary: The study focused on using low-intensity focused ultrasound (LIFU) on the brains of epileptic rats to analyze the impact on the brain network and explored the mechanism of ultrasound neuromodulation. The results showed that LIFU significantly decreased the brain network connection strength across multiple brain regions, especially in the low-frequency band. Additionally, various brain network indicators changed significantly in the low-frequency band after sonication.

BRAIN SCIENCES (2021)

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Article Engineering, Biomedical

Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans

Kai Yu et al.

Summary: Transcranial focused ultrasound (tFUS) is an emerging non-invasive brain stimulation tool that can safely modulate brain circuits. This study demonstrates the neuromodulatory effects of low-intensity tFUS on enhancing human voluntary movement-related cortical activities. The findings suggest that tFUS has the potential to enhance endogenous motor cortical activities through excitatory modulation.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2021)

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Article Acoustics

Transcranial Ultrasound Stimulation of Hypothalamus in Aging Mice

Na Pang et al.

Summary: The study found that transcranial ultrasound stimulation (TUS) of the hypothalamus improved movement and learning behavior in aging mice, as well as significantly increased grip strength and reduced inflammation and apoptosis levels after treatment. However, the effects of TUS were not long-lasting. Overall, TUS may effectively modulate the hypothalamus and provide a new method for controlling aging.

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL (2021)

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Article Clinical Neurology

Transcranial focused ultrasound pulsation suppresses pentylenetetrazol induced epilepsy in vivo

Sin-Guang Chen et al.

BRAIN STIMULATION (2020)

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Article Acoustics

Alleviation Effects and Mechanisms of Low-intensity Focused Ultrasound on Pain Triggered by Soft Tissue Injury

Dandan Liang et al.

JOURNAL OF ULTRASOUND IN MEDICINE (2020)

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Article Neurosciences

Transcranial Focused Ultrasound to the Right Prefrontal Cortex Improves Mood and Alters Functional Connectivity in Humans

Joseph L. Sanguinetti et al.

FRONTIERS IN HUMAN NEUROSCIENCE (2020)

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Article Acoustics

FOCUSED ULTRASOUND PLATFORM FOR INVESTIGATING THERAPEUTIC NEUROMODULATION ACROSS THE HUMAN HIPPOCAMPUS

Spencer T. Brinker et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2020)

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Article Clinical Neurology

Histologic safety of transcranial focused ultrasound neuromodulation and magnetic resonance acoustic radiation force imaging in rhesus macaques and sheep

Pooja Gaur et al.

BRAIN STIMULATION (2020)

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Article Chemistry, Multidisciplinary

Transcranial Pulse Stimulation with Ultrasound in Alzheimer's Disease-A New Navigated Focal Brain Therapy

Roland Beisteiner et al.

ADVANCED SCIENCE (2020)

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Article Acoustics

Ultrasonic stimulation of the brain to enhance the release of dopamine - A potential novel treatment for Parkinsons disease

Tian Xu et al.

ULTRASONICS SONOCHEMISTRY (2020)

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Article Multidisciplinary Sciences

A retrospective qualitative report of symptoms and safety from transcranial focused ultrasound for neuromodulation in humans

Wynn Legon et al.

SCIENTIFIC REPORTS (2020)

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Article Neurosciences

Closed-Loop Transcranial Ultrasound Stimulation for Real-Time Non-invasive Neuromodulation in vivo

Huifang Yang et al.

FRONTIERS IN NEUROSCIENCE (2020)

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Article Neurosciences

Cortical hemodynamic responses induced by low-intensity transcranial ultrasound stimulation of mouse cortex

Yi Yuan et al.

NEUROIMAGE (2020)

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Article Clinical Neurology

Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo

M. S. Bobola et al.

BRAIN STIMULATION (2020)

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Article Clinical Neurology

Sonication of the anterior thalamus with MRI-Guided transcranial focused ultrasound (tFUS) alters pain thresholds in healthy adults: A double-blind, sham-controlled study

Bashar W. Badran et al.

BRAIN STIMULATION (2020)

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Article Behavioral Sciences

Noninvasive Brain Stimulation & Space Exploration: Opportunities and Challenges

S. M. Romanella et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

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Article Biology

Systematic examination of low-intensity ultrasound parameters on human motor cortex excitability an behavior

Anton Fomenko et al.

ELIFE (2020)

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Article Medicine, Research & Experimental

Non-invasive ultrasonic neuromodulation of neuronal excitability for treatment of epilepsy

Zhengrong Lin et al.

THERANOSTICS (2020)

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Article Engineering, Biomedical

Noninvasive Ultrasonic Neuromodulation in Freely Moving Mice

Guofeng Li et al.

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (2019)

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Article Neurosciences

Manipulation of Subcortical and Deep Cortical Activity in the Primate Brain Using Transcranial Focused Ultrasound Stimulation

Davide Folloni et al.

NEURON (2019)

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Article Acoustics

NON-INVASIVE LOW-INTENSITY PULSED ULTRASOUND MODULATES PRIMARY CILIA OF RAT HIPPOCAMPAL NEURONS

Xiaowei Huang et al.

ULTRASOUND IN MEDICINE AND BIOLOGY (2019)

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Article Clinical Neurology

Elimination of peripheral auditory pathway activation does not affect motor responses from ultrasound neuromodulation

Morteza Mohammadjavadi et al.

BRAIN STIMULATION (2019)

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Article Neurosciences

The macaque anterior cingulate cortex translates counterfactual choice value into actual behavioral change

Elsa F. Fouragnan et al.

NATURE NEUROSCIENCE (2019)

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Article Biology

Offline impact of transcranial focused ultrasound on cortical activation in primates

Lennart Verhagen et al.

ELIFE (2019)

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Review Engineering, Biomedical

Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia

Antoine Jerusalem et al.

ACTA BIOMATERIALIA (2019)

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Article Clinical Neurology

Reversible neuroinhibition by focused ultrasound is mediated by a thermal mechanism

David P. Darrow et al.

BRAIN STIMULATION (2019)

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Article Multidisciplinary Sciences

Effects of sonication parameters on transcranial focused ultrasound brain stimulation in an ovine model

Kyungho Yoon et al.

PLOS ONE (2019)

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Article Neurosciences

Neuromodulation with single-element transcranial focused ultrasound in human thalamus

Wynn Legon et al.

HUMAN BRAIN MAPPING (2018)

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Article Engineering, Biomedical

Low-intensity focused ultrasound alters the latency and spatial patterns of sensory-evoked cortical responses in vivo

Jonathan A. N. Fisher et al.

JOURNAL OF NEURAL ENGINEERING (2018)

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Article Multidisciplinary Sciences

Transcranial focused ultrasound neuromodulation of the human primary motor cortex

Wynn Legon et al.

SCIENTIFIC REPORTS (2018)

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Review Clinical Neurology

A Review of the Current Therapies, Challenges, and Future Directions of Transcranial Focused Ultrasound Technology Advances in Diagnosis and Treatment

Vibhor Krishna et al.

JAMA NEUROLOGY (2018)

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Article Neurosciences

Effects of transcranial focused ultrasound on human primary motor cortex using 7T fMRI: a pilot study

Leo Ai et al.

BMC NEUROSCIENCE (2018)

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Article Neurosciences

Transcranial focused ultrasound stimulation of motor cortical areas in freely-moving awake rats

Wonhye Lee et al.

BMC NEUROSCIENCE (2018)

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Article Clinical Neurology

Increased Excitability Induced in the Primary Motor Cortex by Transcranial Ultrasound Stimulation

Benjamin C. Gibson et al.

FRONTIERS IN NEUROLOGY (2018)

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Article Clinical Neurology

Modulation of Cerebellar Cortical Plasticity Using Low-Intensity Focused Ultrasound for Poststroke Sensorimotor Function Recovery

Hongchae Baek et al.

NEUROREHABILITATION AND NEURAL REPAIR (2018)

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Article Clinical Neurology

Transcranial ultrasonic stimulation modulates single-neuron discharge in macaques performing an antisaccade task

Nicolas Wattiez et al.

BRAIN STIMULATION (2017)

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Review Psychiatry

Transcranial focused ultrasound: a new tool for non-invasive neuromodulation

Maria Fini et al.

INTERNATIONAL REVIEW OF PSYCHIATRY (2017)

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Letter Clinical Neurology

Non-Invasive Ultrasonic Thalamic Stimulation in Disorders of Consciousness after Severe Brain Injury: A First-in-Man Report

Martin M. Monti et al.

BRAIN STIMULATION (2016)

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Article Multidisciplinary Sciences

Ultrasound modulates ion channel currents

Jan Kubanek et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Transcranial focused ultrasound stimulation of human primary visual cortex

Wonhye Lee et al.

SCIENTIFIC REPORTS (2016)

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Article Radiology, Nuclear Medicine & Medical Imaging

5th International Symposium on Focused Ultrasound Abstracts

[Anonymous]

JOURNAL OF THERAPEUTIC ULTRASOUND (2016)

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Article Neurosciences

Manipulating neuronal activity in the mouse brain with ultrasound: A comparison with optogenetic activation of the cerebral cortex

Michele E. Moore et al.

NEUROSCIENCE LETTERS (2015)

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Article Multidisciplinary Sciences

Image-Guided Transcranial Focused Ultrasound Stimulates Human Primary Somatosensory Cortex

Wonhye Lee et al.

SCIENTIFIC REPORTS (2015)

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Article Clinical Neurology

Transcranial Focused Ultrasound Modulates Intrinsic and Evoked EEG Dynamics

Jerel Mueller et al.

BRAIN STIMULATION (2014)

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Article Clinical Neurology

Focused Ultrasound-mediated Non-invasive Brain Stimulation: Examination of Sonication Parameters

Hyungmin Kim et al.

BRAIN STIMULATION (2014)

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Article Neurosciences

Transcranial focused ultrasound modulates the activity of primary somatosensory cortex in humans

Wynn Legon et al.

NATURE NEUROSCIENCE (2014)

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Article Multidisciplinary Sciences

Increased Anatomical Specificity of Neuromodulation via Modulated Focused Ultrasound

Edin Mehic et al.

PLOS ONE (2014)

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Article Clinical Neurology

Transcranial Ultrasound (TUS) Effects on Mental States: A Pilot Study

Stuart Hameroff et al.

BRAIN STIMULATION (2013)

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Article Neurosciences

Focused ultrasound-mediated suppression of chemically-induced acute epileptic EEG activity

Byoung-Kyong Min et al.

BMC NEUROSCIENCE (2011)

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Review Clinical Neurology

A review of low-intensity focused ultrasound pulsation

Alexander Bystritsky et al.

BRAIN STIMULATION (2011)

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Article Neurosciences

Transcranial focused ultrasound to the thalamus alters anesthesia time in rats

Seung-Schik Yoo et al.

NEUROREPORT (2011)

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Review Clinical Neurology

Brain stimulation in psychiatry and its effects on cognition

Kate E. Hoy et al.

NATURE REVIEWS NEUROLOGY (2010)

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Transcranial Focused Ultrasound Neuromodulation: A Review of the Excitatory and Inhibitory Effects on Brain Activity in Human and Animals

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