期刊
FRONTIERS IN HUMAN NEUROSCIENCE
卷 15, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2021.755017
关键词
type 2 diabetes mellitus; cognitive impairment; MRI; brain connectivity; network
资金
- Hunan Provincial Science and Technology Innovation Program of China [2017SK50203]
- Scientific Research Fund Project of Hunan Provincial Health Commission [20201911 (HZ)]
- Science and Technology Project of Hengyang [HCJZ20206720]
- Hunan Provincial Natural Science Foundation of China [2018JJ2357]
- Hunan Provincial Innovation Foundation for Postgraduate [CX203YSC066]
Type 2 diabetes is associated with cognitive impairment, and changes in neuronal neuropathies and metabolism affect the structural and functional connections in the brain.
Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment in many domains. There are several pieces of evidence that changes in neuronal neuropathies and metabolism have been observed in T2DM. Structural and functional MRI shows that abnormal connections and synchronization occur in T2DM brain circuits and related networks. Neuroplasticity and energy metabolism appear to be principal effector systems, which may be related to amyloid beta (A beta) deposition, although there is no unified explanation that includes the complex etiology of T2DM with cognitive impairment. Herein, we assume that cognitive impairment in diabetes may lead to abnormalities in neuroplasticity and energy metabolism in the brain, and those reflected to MRI structural connectivity and functional connectivity, respectively.
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