4.5 Review

Altered Structural and Functional MRI Connectivity in Type 2 Diabetes Mellitus Related Cognitive Impairment: A Review

期刊

FRONTIERS IN HUMAN NEUROSCIENCE
卷 15, 期 -, 页码 -

出版社

FRONTIERS MEDIA SA
DOI: 10.3389/fnhum.2021.755017

关键词

type 2 diabetes mellitus; cognitive impairment; MRI; brain connectivity; network

资金

  1. Hunan Provincial Science and Technology Innovation Program of China [2017SK50203]
  2. Scientific Research Fund Project of Hunan Provincial Health Commission [20201911 (HZ)]
  3. Science and Technology Project of Hengyang [HCJZ20206720]
  4. Hunan Provincial Natural Science Foundation of China [2018JJ2357]
  5. Hunan Provincial Innovation Foundation for Postgraduate [CX203YSC066]

向作者/读者索取更多资源

Type 2 diabetes is associated with cognitive impairment, and changes in neuronal neuropathies and metabolism affect the structural and functional connections in the brain.
Type 2 diabetes mellitus (T2DM) is associated with cognitive impairment in many domains. There are several pieces of evidence that changes in neuronal neuropathies and metabolism have been observed in T2DM. Structural and functional MRI shows that abnormal connections and synchronization occur in T2DM brain circuits and related networks. Neuroplasticity and energy metabolism appear to be principal effector systems, which may be related to amyloid beta (A beta) deposition, although there is no unified explanation that includes the complex etiology of T2DM with cognitive impairment. Herein, we assume that cognitive impairment in diabetes may lead to abnormalities in neuroplasticity and energy metabolism in the brain, and those reflected to MRI structural connectivity and functional connectivity, respectively.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.5
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据