4.7 Article

Anti-obesity natural products and gut microbiota

期刊

FOOD RESEARCH INTERNATIONAL
卷 151, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.foodres.2021.110819

关键词

Obesity; Natural products; Gut microbiota; Bacterial messengers

资金

  1. National Key Research and Development Program of China [2017YFC1701105, 2017YFC1701103]
  2. National Natural Science Foundation of China [81922072, 81973443]
  3. National Modern Agricultural Industrial Park of China [njf [2017] 110]
  4. Priority Academic Program Development of Jiangsu Higher Education Institutions [CPU2018GF04]
  5. Project of State Key Laboratory of Natural Medicines (China) [SKLNMZZ202006]

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Studies have shown that natural products have anti-obesity activities that are dependent on gut microbiota. Manipulation of gut microbiota by natural products may serve as a potential therapeutic strategy to prevent obesity.
The link between gut microbiota and obesity or other metabolic syndromes is growing increasingly clear. Natural products are appreciated for their beneficial health effects in humans. Increasing investigations demonstrated that the anti-obesity bioactivities of many natural products are gut microbiota dependent. In this review, we summarized the current knowledge on anti-obesity natural products acting through gut microbiota according to their chemical structures and signaling metabolites. Manipulation of the gut microbiota by natural products may serve as a potential therapeutic strategy to prevent obesity.

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