Differences of gut microbiota composition in mice supplied with polysaccharides from γ-irradiated and non-irradiated Schizophyllum commune

In this study, polysaccharides from normal (N-SFP) and gamma-irradiated (I-SFP) Schizophyllum commune were supplied to Kunming mice for 30 days. The results showed that N-SFP and I-SFP supplementation prevent body weight gain, enhance kidney uric acid metabolism and increase the concentration of SCFAs to a certain extent. Moreover, N-SFP and I-SFP promote the growth of beneficial gut microbiota and inhibit the growth of harmful bacteria. Compared to N-SFP, I-SFP decreased the relative abundance of Muribaculaceae and Lactobacillaceae , and increased the beneficial gut microbiota, especially the family of Akkermansiaceae , Lachnospiraceae and Bacteroidaceae. In total, I-SFP showed better effects than N-SFP in preventing weight gain, and modulating the mice gut microbiota, which suggests that I-SFP could act as a potential health supplement in the prevention of obesity.

Automated summary

Polysaccharides from Schizophyllum commune, both normal and gamma-irradiated, were shown to prevent weight gain, enhance kidney uric acid metabolism, and increase the concentration of SCFAs in mice. Additionally, these polysaccharides promoted the growth of beneficial gut microbiota and inhibited harmful bacteria. Gamma-irradiated polysaccharides demonstrated better effects in preventing weight gain and modulating the gut microbiota of mice, indicating their potential as a health supplement for obesity prevention.