期刊
FOOD HYDROCOLLOIDS
卷 119, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2021.106837
关键词
Hydrophobic nutrient; Carrier; Starch; Stability; Release property
资金
- National Natural Science Foundation of China [31571794, 31560437, JUFSTR20180204]
- Science and Technology Major Project of Guangxi [guikeAA17202029]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_1842]
This study aimed to investigate the controlled release mechanism of Astaxanthin (AST) from biocompatible double emulsions fabricated with a novel two-step emulsification method using native starch. The results showed that AST-loaded SDEs exhibited excellent storage stability, high encapsulation efficiency, and a sustained release profile, with the diffusion-releasing mechanism being the most suitable model for describing the release kinetics. The interaction between SDEs and AST was also explored, highlighting the potential of SDEs as promising oral delivery carriers for lipophilic ingredients.
The aim of the present study was to illuminate the controlled release mechanism of Astaxanthin (AST) from the biocompatible double emulsions fabricated by inexpensive, renewable and biodegradable native starch (SDEs) using a novel two-step emulsification. The storage stability of the four types of AST-loaded SDEs was evaluated. The results indicated that SDEs prepared with a native corn starch concentration of 7 wt% (7% NCS DEs), and a droplet size of approximately 8 mu m without stratification, exhibited excellent storage stability for 35 d. The chemical stability of AST remaining for 7% NCS DEs after 35 d was 90%. The AST-loaded SDEs displayed a high encapsulation efficiency (96%). The release of AST-loaded SDEs was <10% for 120 min in simulated gastric fluid. A sustained and slow release was achieved in simulated intestinal fluid. Moreover, several models have been tested to describe the kinetics of AST release, the most suitable being the diffusion-releasing mechanism. Furthermore, the interaction of SDEs and AST was investigated through steady-state fluorescence measurements and the complexing index. As a demonstration, AST was loaded in the SDEs by hydrophobic interaction and amylose-AST complex formation, enabling the regulation of diffusion and permeation phenomena. Thus, the SDEs are promising oral delivery carriers for lipophilic ingredients.
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