期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 156, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2021.112481
关键词
Advanced glycation endproducts; Receptor of advanced glycation endproduct; Lotus seedpod oligomeric procyanidins; Liver damage; Inhibition
资金
- National Natural Science Foundation of China [32001705, 21908048]
- Key Laboratory of Food Nutrition and Functional Food of Hainan Province [KF202009]
- State Key Laboratory of Marine Resource Utilization in South China Sea (Hainan University) [MRUKF2021002]
- HBUT National 111 Center for Cellular Regulation and Molecular Pharmaceutics [XBTK-2020005]
The study demonstrated that LSOPC inhibited AGEs formation, alleviated AGEs-induced liver injury by suppressing NF-kappa B nuclear translocation and MAPK signaling pathway activation. Additionally, LSOPC also inhibited the expression of TNF-alpha and IL-6. In conclusion, LSOPC treatment potentially modulated liver injury caused by long-term dietary AGEs by suppressing the RAGE-MAPK-NF-kappa B pathways.
This study investigated the modulatory effects of lotus seedpod oligomeric procyanidins (LSOPC) on the advanced glycation endproducts (AGEs)-induced liver injury via advanced glycation end-product receptors (RAGE)-mitogen-activated protein kinases (MAPK)-nuclear factor-kappa B (NF-kappa B) signaling pathways in a mice model. To examine the antioxidation properties of LSOPC, a model of high-AGEs-diet were established using Sprague Dawley (SD) male mice fed with a normal AIN-93G diet, a high AGEs diet (H), or H plus 0.5 or 0.2% (w/w) LSOPC for 12 weeks. Our results showed that LSOPC inhibited the AGEs formation and alleviated AGEsinduced liver injury by suppressing the nuclear translocation of NF-kappa B and activation of the MAPK signaling pathway. Additionally, LSOPC inhibited the genes expression of tumor necrosis factor-alpha (TNF-alpha) and interleukin 6 (IL-6). Taken together, LSOPC treatment potentially inhibited the AGEs formation and modulated liver injury with long-term dietary AGEs by suppressing RAGE-MAPK-NF-kappa B pathways.
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