Triterpenoids from the fruiting bodies of Ganoderma lucidum and their inhibitory activity against FAAH

Seventeen triterpenoids including four new lanostane triterpenoids (1-3 and 5) were isolated from the fruiting bodies of Ganoderma lucidum by various chromatographic techniques. Their chemical structures were determined by extensive spectroscopic data, including 1D-NMR, 2D-NMR, and HRESIMS. In addition, the spectral data of compound 4 was reported for the first time. In an in vitro bioassay, most isolated triterpenoids could inhibit the hydrolysis activity of fatty acid amide hydrolase (FAAH). Furthermore, there is no cytotoxicity observed for these isolated triterpenoids. Therefore, G. lucidum showed the potential application for anti-neuroinflammation and more FAAH inhibitors may be explored from G. lucidum.

Automated summary

Four new lanostane triterpenoids were isolated from the fruiting bodies of Ganoderma lucidum, which showed potential application for anti-neuroinflammation by inhibiting the activity of FAAH without cytotoxicity.