期刊
FEMS MICROBIOLOGY LETTERS
卷 369, 期 1, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1093/femsle/fnac019
关键词
Staphylococcus pseudintermedius; atopic dermatitis; IgE; dogs; DM13-domain-containing protein; exacerbation factor
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资金
- Azabu University
Staphylococcus pseudintermedius is a major pathogen causing canine skin infection, and it likely exacerbates the severity of canine atopic dermatitis (AD). This study investigated the IgE reactivities to different strains of S. pseudintermedius and identified several IgE-reactive proteins. The findings suggest that S. pseudintermedius may worsen AD in dogs differently from Staphylococcus aureus in human AD.
Staphylococcus pseudintermedius is one of the major pathogens causing canine skin infection. In canine atopic dermatitis (AD), heterogeneous strains of S. pseudintermedius reside on the affected skin site. Because an increase in specific IgE to this bacterium has been reported, S. pseudintermedius is likely to exacerbate the severity of canine AD. In this study, the IgE reactivities to various S. pseudintermedius strains and the IgE-reactive molecules of S. pseudintermedius were investigated. First, examining the IgE reactivities to eight strains of S. pseudintermedius using 141 sera of AD dogs, strain variation of S. pseudintermedius showed 10-63% of the IgE reactivities. This is different from the expected result based on the concept of Staphylococcus aureus clonality in AD patients. Moreover, according to the western blot analysis, there were more than four proteins reactive to IgE. Subsequently, the analysis of the common IgE-reactive protein at similar to 15 kDa confirmed that the DM13-domain-containing protein was reactive in AD dogs, which is not coincident with any S. aureus IgE-reactive molecules. Considering these, S. pseudintermedius is likely to exacerbate AD severity in dogs, slightly different from the case of S. aureus in human AD. IgE reactivities to Staphylococcus pseudintermedius.
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