期刊
FEBS LETTERS
卷 596, 期 10, 页码 1299-1312出版社
WILEY
DOI: 10.1002/1873-3468.14264
关键词
chemical reactivity; l-ergothioneine; molecular biological activities; nucleophile; protein ligand; reductant
This article provides a review on how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine, and reveals a new perspective of the function and mode of action of this enigmatic molecule based on its physicochemical properties.
l-ergothioneine is a low-molecular weight natural product, the chemical structure of which comprises oxygen-, nitrogen- and sulfur-containing functional groups. This gives l-ergothioneine specific physicochemical properties and allows a better understanding of its chemical reactivity, which is primarily due to the 2-thio-imidazole group. Here, a review is provided of how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine. By matching the physicochemical properties to the biological properties of l-ergothioneine, a new perspective of the function and the mode of action of this enigmatic molecule emerges.
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