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Matching chemical properties to molecular biological activities opens a new perspective on l-ergothioneine

期刊

FEBS LETTERS
卷 596, 期 10, 页码 1299-1312

出版社

WILEY
DOI: 10.1002/1873-3468.14264

关键词

chemical reactivity; l-ergothioneine; molecular biological activities; nucleophile; protein ligand; reductant

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This article provides a review on how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine, and reveals a new perspective of the function and mode of action of this enigmatic molecule based on its physicochemical properties.
l-ergothioneine is a low-molecular weight natural product, the chemical structure of which comprises oxygen-, nitrogen- and sulfur-containing functional groups. This gives l-ergothioneine specific physicochemical properties and allows a better understanding of its chemical reactivity, which is primarily due to the 2-thio-imidazole group. Here, a review is provided of how different modes of chemical reactivity account for the reported molecular biological activities of l-ergothioneine. By matching the physicochemical properties to the biological properties of l-ergothioneine, a new perspective of the function and the mode of action of this enigmatic molecule emerges.

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