4.6 Review

Neuroimmune regulation of white adipose tissues

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Summary: This article discusses the role of innate immune cells in adipose tissue in obese states, and how these cells are influenced by the obesogenic microenvironment and humoral, paracrine, and cellular interactions. Additionally, it outlines the significant role of hypoxia in adipose tissue inflammation.

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Interferon-α-producing plasmacytoid dendritic cells drive the loss of adipose tissue regulatory T cells during obesity

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Macrophage beta2-adrenergic receptor is dispensable for the adipose tissue inflammation and function

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Sympathetic but not sensory denervation stimulates white adipocyte proliferation

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White adipose tissue lacks significant vagal innervation and immunohistochemical evidence of parasympathetic innervation

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Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans

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White adipose tissue sensory nerve denervation mimics lipectomy-induced compensatory increases in adiposity

HF Shi et al.

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Diet induction of monocyte chemoattractant protein-1 and its impact on obesity

AR Chen et al.

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Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity

HF Shi et al.

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Production and release of macrophage migration inhibitory factor from human adipocytes

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TNFa release by the nonfat cells of human adipose tissue

JN Fain et al.

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Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects

K Clément et al.

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Sema3A and neuropilin-1 expression and distribution in rat white adipose tissue

A Giordano et al.

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Obesity is associated with macrophage accumulation in adipose tissue

SP Weisberg et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Medicine, Research & Experimental

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

HY Xu et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Cell Biology

Chemokines control fat accumulation and leptin secretion by cultured human adipocytes

CC Gerhardt et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2001)

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Significance of chemokines and activated platelets in patients with diabetes

S Nomura et al.

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Article Cell Biology

Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

J Himms-Hagen et al.

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