4.7 Review

cGAS-STING signaling pathway in gastrointestinal inflammatory disease and cancers

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DNA damage repair promotion in colonic epithelial cells by andrographolide downregulated cGAS-STING pathway activation and contributed to the relief of CPT-11-induced intestinal mucositis

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A Nuclear Export Signal Is Required for cGAS to Sense Cytosolic DNA

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5-Fluorouracil efficacy requires anti-tumor immunity triggered by cancer-cell-intrinsic STING

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STING agonist and IDO inhibitor combination therapy inhibits tumor progression in murine models of colorectal cancer

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Summary: Alterations in the cGAS-STING DNA-sensing pathway can affect intestinal homeostasis and lead to inflammation. Increased STING expression is a feature of intestinal inflammation in both mice with colitis and humans with inflammatory bowel disease. STING accumulation in intestinal myeloid cells can be triggered by dysbiosis and bacterial products, leading to a positive feedback loop that drives intestinal inflammation.

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Identification and validation of the prognostic value of cyclic GMP-AMP synthase-stimulator of interferon (cGAS-STING) related genes in gastric cancer

Kui-Sheng Yang et al.

Summary: This study aimed to develop a prediction model for gastric cancer prognosis based on cGAS-STING pathway-related genes, using TCGA, GEO, CIBERSORT, and TIMER databases. The risk model constructed from five hub genes was proven to be an independent prognostic factor. Immune cell infiltration analysis revealed differences in the immune microenvironment between high and low-risk groups.

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Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation

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STING-Dependent Interferon-λ1 Induction in HT29 Cells, a Human Colorectal Cancer Cell Line, After Gamma-Radiation

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