期刊
EXPERT OPINION ON INVESTIGATIONAL DRUGS
卷 31, 期 6, 页码 499-513出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13543784.2021.1972968
关键词
Immunotherapy; triple negative breast cancer; TNBC; next-generation immune-checkpoint inhibitors; clinical trials; breast cancer
The article discusses the immune landscape of TNBC and the rationale of NGIO in early development, highlighting challenges and opportunities. Multiple immunotherapeutic strategies beyond PD-(L)1 blockade have shown safety and early signs of antitumor activity. Refining patient selection based on emerging immune biomarkers and adapting immunotherapeutic strategies based on patient and tumor characteristics will be crucial for optimal harnessing the potential of NGIO.
Introduction Immunotherapy through the blockade of PD1-PDL1 axis has shown to improve outcomes in advanced and early triple negative breast cancer (TNBC). To further enhance immune-stimulation, and ultimately improve patient outcomes, a wide variety of next-generation immunotherapies (NGIO) is being developed for this disease. Areas covered In the present article, we discuss the immune landscape of TNBC and recapitulate the rationale and available clinical evidence of NGIO under early phase development for TNBC, highlighting challenges and opportunities in this emerging field of research. Expert opinion Multiple immunotherapeutic strategies beyond PD-(L)1 blockade have been tested for TNBC, including the targeting of further inhibitory checkpoints, the agonism of costimulatory molecules, the intratumoral administration of immunotherapies and cancer vaccines. Most of these strategies have demonstrated to be safe in early clinical trials, with some exhibiting early signs of antitumor activity. To optimally harness the potential of NGIO, a refined patient selection based on emerging immune biomarkers will be required, through an adaptation of immunotherapeutic strategies based on patient and tumor characteristics. More mature data from ongoing clinical trials, added to the progressively increasing knowledge on breast cancer immune landscape, will hopefully clarify the role of NGIO for the treatment of TNBC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据