4.5 Review

Gut microbiota-drug interactions in cancer pharmacotherapies: implications for efficacy and adverse effects

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Oncology

Association of Antibiotic Exposure With Survival and Toxicity in Patients With Melanoma Receiving Immunotherapy

Jahan J. Mohiuddin et al.

Summary: For patients with stage III and IV melanoma who had prior exposure to antibiotics before receiving immune checkpoint inhibitors (ICI), they had significantly worse overall survival and a higher incidence of immune-mediated colitis compared to unexposed patients.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2021)

Review Microbiology

Gut microbial metabolites as multi-kingdom intermediates

Kimberly A. Krautkramer et al.

Summary: The gut microbiota influences host physiology through the production of various metabolites. By studying microbial metabolites, researchers have identified potential microbial targets relevant for host health, despite the challenges of understanding host-microbiota interactions.

NATURE REVIEWS MICROBIOLOGY (2021)

Review Oncology

Microbiome-gut-brain axis in cancer treatment-related psychoneurological toxicities and symptoms: a systematic review

Byron Chang Song et al.

Summary: The microbiome-gut-brain (MGB) axis plays a role in understanding the connection between gut microbiota and psychoneurological comorbidities. This systematic review on six studies found significant associations between gut microbiota and cancer treatment-related psychoneurological symptoms (PNS), particularly in cancer survivors undergoing chemotherapy. The relative abundance of specific microbiota was linked to fear of cancer recurrence, fatigue, anxiety, depression, sleep disturbance, cognitive impairment, and chemotherapy-induced peripheral neuropathy.

SUPPORTIVE CARE IN CANCER (2021)

Article Nutrition & Dietetics

Effects of dietary fibre intake in chemotherapy-induced mucositis in murine model

B. Gallotti et al.

Summary: The study demonstrated that a high-fibre diet could reduce immune cell infiltration and improve histopathological parameters in the intestine, decrease intestinal permeability, modulate intestinal microbiota, and maintain gut homeostasis during mucositis in a murine model. On the other hand, a low/zero fibre diet exacerbated gut permeability and increased levels of Enterobacteriaceae associated with gut inflammation.

BRITISH JOURNAL OF NUTRITION (2021)

Article Biochemistry & Molecular Biology

Infection trains the host for microbiota-enhanced resistance to pathogens

Apollo Stacy et al.

Summary: The research shows that gut microbiota from previously infected hosts have enhanced resistance to infection, associated with altered bile acid metabolism and expansion of taxa that utilize taurine. The supply of exogenous taurine alone can induce this alteration and enhance resistance. Mechanistically, taurine potentiates the microbiota's production of sulfide, inhibiting cellular respiration and promoting resistance to pathogen invasion.
Article Biochemistry & Molecular Biology

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

Francesco Asnicar et al.

Summary: The gut microbiome is influenced by diet and has significant associations with nutrients, foods, and overall dietary habits, impacting host metabolism and cardiovascular disease risk. Certain microbial species are indicators of favorable postprandial glucose metabolism, while overall microbiome composition can predict a range of cardiometabolic blood markers.

NATURE MEDICINE (2021)

Article Multidisciplinary Sciences

Predicting drug-metagenome interactions: Variation in the microbial β-glucuronidase level in the human gut metagenomes

Moamen M. Elmassry et al.

Summary: Characterizing the gut microbiota's ability to affect drug metabolism is crucial for drug efficacy and safety. This study developed a computational approach to identify bacterial enzymes that process specific classes of drugs, using beta-glucuronidases as an example. Analysis revealed differences in enzyme levels between males and females, potentially explaining sex-based disparities in drug response, and highlighted the variability in newborn and infant gut metagenomes.

PLOS ONE (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Erez N. Baruch et al.

Summary: This study conducted a phase 1 clinical trial and found that FMT treatment in patients with anti-PD-1-refractory metastatic melanoma, along with reinduction of anti-PD-1 immunotherapy, resulted in clinical responses in some patients. This suggests that modulating the gut microbiota could be a promising approach in cancer treatment.

SCIENCE (2021)

Article Microbiology

Bifidobacterium bifidum strains synergize with immune checkpoint inhibitors to reduce tumour burden in mice

Se-Hoon Lee et al.

Summary: Specific strains of Bifidobacterium bifidum can reduce tumor burden synergistically with PD-1 blockade or oxaliplatin treatment by eliciting an antitumor host immune response, indicating their potential therapeutic use.

NATURE MICROBIOLOGY (2021)

Article Peripheral Vascular Disease

Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors

Samir V. Jenkins et al.

Summary: This study demonstrates that antibiotic-induced dysbiosis affects the sensitivity of tumor endothelial cells to cancer therapy, and targeting the c-Met pathway associated with tumor endothelial cells during dysbiosis may greatly improve tumor response in patients.

ANGIOGENESIS (2021)

Review Rheumatology

TNF in the era of immune checkpoint inhibitors: friend or foe?

Allen Y. Chen et al.

Summary: TNF inhibitors are commonly used to treat immune-related adverse events induced by immune checkpoint inhibitors, and evidence suggests that short courses of TNF inhibitors are safe for treating these events in cancer patients undergoing ICI therapy. Preclinical studies hint that TNF inhibition might enhance the antitumour effect of ICI therapy while ameliorating immune-related adverse events.

NATURE REVIEWS RHEUMATOLOGY (2021)

Article Multidisciplinary Sciences

A prospective study of the adaptive changes in the gut microbiome during standard-of-care chemoradiotherapy for gynecologic cancers

Molly B. El Alam et al.

Summary: Pelvic chemoradiotherapy leads to a continuous decrease in gut microbiome diversity, but around 60% of patients reach baseline levels by week 12. Patients with higher gut diversity at baseline experience a more significant decline during therapy. The composition of the gut microbiome changes significantly during and after therapy, with subsequent adaptation.

PLOS ONE (2021)

Article Multidisciplinary Sciences

Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients

Diwakar Davar et al.

Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.

SCIENCE (2021)

Article Virology

Common Oral Medications Lead to Prophage Induction in Bacterial Isolates from the Human Gut

Steven G. Sutcliffe et al.

Summary: The study revealed that common medications at gut-predicted concentrations can induce phages in human gut bacteria, potentially altering the human gut microbiome. Unlike antibiotics, host-targeted medications led to species-specific induction effects.

VIRUSES-BASEL (2021)

Article Oncology

Bifidobacterium Strain-Specific Enhances the Efficacy of Cancer Therapeutics in Tumor-Bearing Mice

Youngmin Yoon et al.

Summary: The efficacy of cancer therapeutics depends on various factors such as the tumor genome and immune response. This study shows that the gut microbiome plays a significant role in regulating immune responses and influencing cancer treatment outcomes. Supplementing with specific microbiota like B. breve strains can enhance anti-tumor immunity and potentially improve the efficacy of colorectal cancer therapeutics.

CANCERS (2021)

Article Oncology

Analysis of Gut Microbiome Using Explainable Machine Learning Predicts Risk of Diarrhea Associated With Tyrosine Kinase Inhibitor Neratinib: A Pilot Study

Chi Wah Wong et al.

Summary: In a pilot study on patients with HER2+ breast cancer, specific microbiota associated with reduced risk of neratinib-induced diarrhea were identified, providing important insights for further research.

FRONTIERS IN ONCOLOGY (2021)

Article Biology

Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation

Travis T. Sims et al.

Summary: The diversity of gut microbiota is associated with a favorable response to chemoradiation in cervical cancer patients. Variations in microbiota composition among patients correlate with short term and long-term survival outcomes. Analysis showed that patients with high microbiome diversity had increased tumor infiltration of certain immune cells throughout radiation therapy, suggesting a potential way to enhance treatment efficacy and outcomes.

COMMUNICATIONS BIOLOGY (2021)

Article Immunology

Manipulations of the gut microbiome alter chemotherapy-induced inflammation and behavioral side effects in female mice

C. V. Grant et al.

Summary: Chemotherapy treatment is linked to acute behavioral side effects that impact patient quality of life and are associated with disruptions to gut homeostasis. Studies suggest a possible relationship between gut microbiota and chemotherapy side effects, but the underlying mechanisms are not well understood.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Biochemistry & Molecular Biology

Intestinal microbiota influences clinical outcome and side effects of early breast cancer treatment

Safae Terrisse et al.

Summary: This study found that specific gut commensals overabundant in breast cancer patients compared with healthy individuals have a negative impact on the prognosis of breast cancer, are modulated by chemotherapy, and may influence weight gain and neurological side effects of breast cancer therapies. Further prospective validation of these findings in adjuvant and neoadjuvant settings is warranted.

CELL DEATH AND DIFFERENTIATION (2021)

Review Cell Biology

Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet

Diana E. Gutierrez Lopez et al.

Summary: The gut microbiome and the molecular circadian clock both play essential roles in optimizing the host's metabolism, by breaking down nutrients and influencing metabolic processes, respectively. Their interactions have significant effects on obesity and energy homeostasis, highlighting potential therapeutic strategies in addressing metabolic diseases.

CELL METABOLISM (2021)

Article Oncology

The effects of antibiotics on the efficacy of immune checkpoint inhibitors in patients with non-small-cell lung cancer differ based on PD-L1 expression

Nobuaki Ochi et al.

Summary: The study showed that the impact of ATB use on the efficacy of ICIs in NSCLC patients depends on the level of PD-L1 expression. Patients with PD-L1 expression >50% who received ATBs had significantly shorter PFS and OS, while there was no significant impact on patients with PD-L1 expression <50%.

EUROPEAN JOURNAL OF CANCER (2021)

Review Oncology

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Kai Tang et al.

Summary: IDO1 is an important heme enzyme involved in cancer immune escape, associated with poor prognosis in various cancers, and currently undergoing clinical trials with multiple drugs. The development of IDO1 degraders using PROTAC technology presents a novel therapeutic approach.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Article Biochemistry & Molecular Biology

Fecal Metabolic Profiling of Breast Cancer Patients during Neoadjuvant Chemotherapy Reveals Potential Biomarkers

Oumaima Zidi et al.

Summary: Breast cancer is the most common form of cancer among women worldwide, and alterations in gut microbiome-derived metabolites may promote its development. Analysis of fecal metabolites from treated patients revealed significant changes in metabolic profiles influenced by chemotherapy.

MOLECULES (2021)

Article Microbiology

Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum

Caitlin A. Brennan et al.

Summary: The study demonstrates that aspirin has specific antibacterial effects on Fusobacterium nucleatum, a bacterium associated with colorectal cancer. Individuals who use aspirin daily have lower levels of this bacterium in colon adenoma tissues. This suggests the potential for aspirin to modulate bacteria in vivo for improved colorectal cancer outcomes.
Review Environmental Sciences

Probiotic Supplements on Oncology Patients' Treatment-Related Side Effects: A Systematic Review of Randomized Controlled Trials

Miguel Rodriguez-Arrastia et al.

Summary: Probiotics supplements show potential positive effects in reducing treatment-related side effects in oncology patients. While some studies reported no impact, the majority demonstrated the potential of probiotics in preventing or mitigating treatment-related side effects. Additionally, the study emphasizes the importance of chemotherapy and radiotherapy in altering the composition of gut microbiota.

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH (2021)

Article Microbiology

The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Sharon Ann Barretto et al.

Summary: This study identified PXR as a hepatic effector of microbiota-derived signals that regulate sexually dimorphic lipid and xenobiotic metabolisms in the liver. These findings reveal a potential new mechanism for unexpected drug-drug interactions.

MICROBIOME (2021)

Article Oncology

Differential influence of antibiotic therapy and other medications on oncological outcomes of patients with non-small cell lung cancer treated with first-line pembrolizumab versus cytotoxic chemotherapy

Alessio Cortellini et al.

Summary: The study reveals the negative impact of antibiotics (ATB) on pembrolizumab monotherapy outcomes in NSCLC, while corticosteroids and proton pump inhibitors (PPIs) may worsen baseline performance status. These findings highlight the underlying immune-modulatory effects of these concomitant medications.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2021)

Review Oncology

Gut Microbiota as Potential Biomarker and/or Therapeutic Target to Improve the Management of Cancer: Focus on Colibactin-Producing Escherichia coli in Colorectal Cancer

Julie Veziant et al.

Summary: The gut microbiota is being recognized as a important factor in cancer management, with microbial markers being used to predict treatment responses. Colibactin-producing E. coli, prevalent in colorectal cancer patients, show potential as a new predictive factor and therapeutic target in colon cancer.

CANCERS (2021)

Article Biochemistry & Molecular Biology

Effects of Chronic Oral Probiotic Treatment in Paclitaxel-Induced Neuropathic Pain

Mariarosaria Cuozzo et al.

Summary: Research has shown the efficacy of probiotic formulations in preventing chemotherapy-induced peripheral neuropathy, reducing inflammation, modulating pain receptor expression, preserving gut functionality, and preventing increased pain sensitivity. These probiotic treatments may be a useful and non-toxic adjuvant agent to improve long-term therapies for patients undergoing chemotherapy.

BIOMEDICINES (2021)

Review Medicine, Research & Experimental

Role of microbiota-derived short-chain fatty acids in cancer development and prevention

Rasoul Mirzaei et al.

Summary: Recent studies have indicated the significant roles of gut microbiota and SCFAs in cancer development, affecting cell survival, differentiation, proliferation, and death. Manipulating the microbiota structure to regulate SCFA levels could potentially offer new strategies for cancer treatment/prevention.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Oncology

Conventional myelosuppressive chemotherapy for non-haematological malignancy disrupts the intestinal microbiome

Lito E. Papanicolas et al.

Summary: Conventional myelosuppressive chemotherapy results in significant changes in gut microbiota characteristics during the predicted myelosuppression period post-chemotherapy, but these changes are no longer significant at the end of the chemotherapy cycle. Further research is needed to link microbiome changes during chemotherapy to clinical outcomes.

BMC CANCER (2021)

Review Oncology

The gut microbiome: what the oncologist ought to know

K. A. Lee et al.

Summary: The gut microbiome (GM) plays a crucial role in human pathologies and has become a focus in oncology research, with emerging evidence supporting its effects on cancer development and responses to therapies. Understanding of the complex interrelationships between GM, cancer, the immune system, nutrition, and medication is based on clinical trials, observational studies, and evolving understanding of cancer biology.

BRITISH JOURNAL OF CANCER (2021)

Article Biochemistry & Molecular Biology

Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Miles C. Andrews et al.

Summary: The study showed that tumor-associated immune and genomic biomarkers of response to combined immune checkpoint blockade (CICB) in melanoma patients were similar to those of monotherapy, while toxicity from CICB was associated with a more diverse peripheral T-cell repertoire. Additionally, analysis of gut microbiota revealed a higher abundance of Bacteroides intestinalis in patients experiencing toxicity, along with an upregulation of the inflammatory factor IL-1 beta in colitis samples.

NATURE MEDICINE (2021)

Review Medical Laboratory Technology

Influence of immunomodulatory drugs on the gut microbiota

Inessa Cohen et al.

Summary: Immunomodulatory medications are a key treatment for autoimmune diseases and cancers, affecting both immune cells and gut microbiota. Despite varied effects on microbiota, most immunotherapies are linked to shifts in specific bacterial taxa. The relationship between drug efficacy and colonizing microbes remains poorly understood, emphasizing the need for further research.

TRANSLATIONAL RESEARCH (2021)

Article Multidisciplinary Sciences

Gut microbiota diversity after autologous fecal microbiota transfer in acute myeloid leukemia patients

Florent Malard et al.

Summary: This study evaluates the efficacy of autologous fecal microbiota transfer (AFMT) in correcting dysbiosis and eradicating multidrug-resistant bacteria in AML patients undergoing intensive chemotherapy and antibiotics. The results show that AFMT is safe and effective for restoring gut microbiota, improving richness, and diversity indices at the species level.

NATURE COMMUNICATIONS (2021)

Article Microbiology

Biotransformation of Doxorubicin Promotes Resilience in Simplified Intestinal Microbial Communities

Ryan A. Blaustein et al.

Summary: This study found that bacteria with biotransformation resistance can effectively reduce doxorubicin concentrations in vitro, protecting drug-sensitive strains and promoting gut health during cancer treatment. In mixed communities, resilience of drug-sensitive members depends on the presence and efficiency of transformers, highlighting the importance of microbiota interactions in promoting gut health during chemotherapy.

MSPHERE (2021)

Article Oncology

Antacid exposure and immunotherapy outcomes among patients with advanced hepatocellular carcinoma

Tomi Jun et al.

Summary: This study found that exposure to PPI/H2RA prior to ICIs does not adversely affect outcomes in HCC patients, including overall survival, overall response rate, and treatment-related adverse events.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

Article Oncology

Acquired resistance to anti-MAPK targeted therapy confers an immune-evasive tumor microenvironment and cross-resistance to immunotherapy in melanoma

Lisa Haas et al.

Summary: The study reveals that tumors relapsing after targeted therapy show cross-resistance to immunotherapies due to an immunosuppressive tumor microenvironment lacking CD103(+) dendritic cells. Cross-resistance is not a result of immune response pressure during resistance evolution, but stems from the MAPK pathway's increased transcriptional output driving immune evasion. Restoring CD103(+) dendritic cells can resensitize tumors to immunotherapy.

NATURE CANCER (2021)

Article Oncology

Antitumor efficacy of a neoantigen cancer vaccine delivered by electroporation is influenced by microbiota composition

Lucia Lione et al.

Summary: The study found that decreased microbiota diversity induced by prolonged antibiotic treatment is associated with higher intratumor specific immune responses and consequently leads to a better antitumor effect induced by NCV delivered by DNA-EP.

ONCOIMMUNOLOGY (2021)

Article Oncology

Associations between dysbiosis-inducing drugs, overall survival and tumor response in patients treated with immune checkpoint inhibitors

Louis Gaucher et al.

Summary: Conflicting data exist on the effects of dysbiosis-inducing drugs, particularly antibiotics, on clinical outcomes in patients treated with immune checkpoint inhibitors. A retrospective study found that antibiotic use was associated with poorer clinical outcomes in patients treated with ICIs, especially those with melanoma, while other dysbiosis-inducing drugs did not show a significant impact on overall survival.

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY (2021)

Article Immunology

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers

Allyson L. Byrd et al.

Summary: This study found that the microbiome is associated with host factors such as biological sex, age, and disease state, with sex being the strongest driver of community composition. Microbial populations shift across age groups and disease states, displaying predictable variations.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

Article Oncology

Randomized trial assessing impact of probiotic supplementation on gut microbiome and clinical outcome from targeted therapy in metastatic renal cell carcinoma

Nazli Dizman et al.

Summary: The study indicates a connection between the gut microbiome and outcomes in mRCC patients, with probiotic supplementation potentially modulating the gut microbiome and affecting the clinical results of VEGF-TKIs. The probiotic yogurt product containing Bifidobacterium successfully increased levels of the bacteria, while certain enriched species like Barnesiella intestinihominis and Akkermansia muciniphila may be associated with clinical benefit.

CANCER MEDICINE (2021)

Article Oncology

Metagenome association study of the gut microbiome revealed biomarkers linked to chemotherapy outcomes in locally advanced and advanced lung cancer

Zhe Zhao et al.

Summary: This study revealed that lung cancer patients with different gut microbiome compositions and microbiome metabolic pathways have varying responses to chemotherapy. Microbiome species are also associated with different lung cancer clinical phenotypes.

THORACIC CANCER (2021)

Review Oncology

Potential Effect of Immunotherapy Agents on Cognitive Function in Cancer Patients

Florence Joly et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2020)

Review Endocrinology & Metabolism

You've got male: Sex and the microbiota-gut-brain axis across the lifespan

Minal Jaggar et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2020)

Article Medicine, Research & Experimental

Gut metabolomics profiling of non-small cell lung cancer (NSCLC) patients under immunotherapy treatment

Andrea Botticelli et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2020)

Article Cell Biology

Engineered probiotics for local tumor delivery of checkpoint blockade nanobodies

Candice R. Gurbatri et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Review Pharmacology & Pharmacy

The gut microbiome: an orchestrator of xenobiotic metabolism

Stephanie L. Collins et al.

ACTA PHARMACEUTICA SINICA B (2020)

Review Gastroenterology & Hepatology

Gastrointestinal adverse events associated with immune checkpoint inhibitor therapy

Eva Rajha et al.

GASTROENTEROLOGY REPORT (2020)

Article Gastroenterology & Hepatology

Impact of host and environmental factors on beta-glucuronidase enzymatic activity: implications for gastrointestinal serotonin

Jacinta Walsh et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Review Medicine, Research & Experimental

Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases

Lien D. Nguyen et al.

EMBO MOLECULAR MEDICINE (2020)

Article Microbiology

Predictable modulation of cancer treatment outcomes by the gut microbiota

Yoshitaro Heshiki et al.

MICROBIOME (2020)

Article Multidisciplinary Sciences

Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy

Aadra P. Bhatt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

The human tumor microbiome is composed of tumor type-specific intracellular bacteria

Deborah Nejman et al.

SCIENCE (2020)

Article Multidisciplinary Sciences

Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity

Daniel S. Leventhal et al.

NATURE COMMUNICATIONS (2020)

Article Multidisciplinary Sciences

Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Clelia Coutzac et al.

NATURE COMMUNICATIONS (2020)

Review Medicine, General & Internal

Survival of Patients Treated with Antibiotics and Immunotherapy for Cancer: A Systematic Review and Meta-Analysis

Fausto Petrelli et al.

JOURNAL OF CLINICAL MEDICINE (2020)

Article Pharmacology & Pharmacy

Effects of gut microbiota on in vivo metabolism and tissue accumulation of cytochrome P450 3A metabolized drug: Midazolam

Masao Togao et al.

BIOPHARMACEUTICS & DRUG DISPOSITION (2020)

Review Health Care Sciences & Services

Pitfalls and novel experimental approaches to optimize microbial interventions for chemotherapy-induced gastrointestinal mucositis

Ana R. da Silva Ferreira et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2020)

Article Oncology

Antibiotics Modulate Chemotherapy Efficacy in Patients with Esophageal Cancer

Chensi Wu et al.

CANCER MANAGEMENT AND RESEARCH (2020)

Article Biochemistry & Molecular Biology

Human postprandial responses to food and potential for precision nutrition

Sarah E. Berry et al.

NATURE MEDICINE (2020)

Article Multidisciplinary Sciences

Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy

Lukas F. Mager et al.

SCIENCE (2020)

Review Clinical Neurology

Gut microbiota regulates neuropathic pain: potential mechanisms and therapeutic strategy

Binbin Lin et al.

JOURNAL OF HEADACHE AND PAIN (2020)

Review Behavioral Sciences

The microbiota-gut-brain axis: An emerging therapeutic target in chemotherapy-induced cognitive impairment

Courtney B. Subramaniam et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2020)

Article Multidisciplinary Sciences

Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade

Shan Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Biochemistry & Molecular Biology

Network Analysis of Gut Microbiome and Metabolome to Discover Microbiota-Linked Biomarkers in Patients Affected by Non-Small Cell Lung Cancer

Pamela Vernocchi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

Glioma and temozolomide induced alterations in gut microbiome

Anthony Patrizz et al.

SCIENTIFIC REPORTS (2020)

Article Health Care Sciences & Services

Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients

Ilaria Grazia Zizzari et al.

JOURNAL OF PERSONALIZED MEDICINE (2020)

Review Pharmacology & Pharmacy

Gastrointestinal side effects of cancer treatments

Mary O'Reilly et al.

THERAPEUTIC ADVANCES IN CHRONIC DISEASE (2020)

Article Multidisciplinary Sciences

Host variables confound gut microbiota studies of human disease

Ivan Vujkovic-Cvijin et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Combined cytotoxic chemotherapy and immunotherapy of cancer: modern times

Christian Bailly et al.

NAR CANCER (2020)

Review Gastroenterology & Hepatology

The aryl hydrocarbon receptor as a mediator of host-microbiota interplay

Fangcong Dong et al.

GUT MICROBES (2020)

Review Biochemistry & Molecular Biology

The microbiome, cancer, and cancer therapy

Beth A. Helmink et al.

NATURE MEDICINE (2019)

Review Pharmacology & Pharmacy

Gut Reactions: Breaking Down Xenobiotic-Microbiome Interactions

Gerard Clarke et al.

PHARMACOLOGICAL REVIEWS (2019)

Review Pharmacology & Pharmacy

Pharmacomicrobiomics: The Holy Grail to Variability in Drug Response?

Anukriti Sharma et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

Article Multidisciplinary Sciences

Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases

Jason Lloyd-Price et al.

NATURE (2019)

Review Gastroenterology & Hepatology

The role of short-chain fatty acids in microbiota-gut-brain communication

Boushra Dalile et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Multidisciplinary Sciences

Mapping human microbiome drug metabolism by gut bacteria and their genes

Michael Zimmermann et al.

NATURE (2019)

Article Biochemistry & Molecular Biology

Programmable bacteria induce durable tumor regression and systemic antitumor immunity

Sreyan Chowdhury et al.

NATURE MEDICINE (2019)

Article Biochemistry & Molecular Biology

Tumor Microbiome Diversity and Composition Influence Pancreatic Cancer Outcomes

Erick Riquelme et al.

Review Gastroenterology & Hepatology

Gut microbiota in colorectal cancer: mechanisms of action and clinical applications

Sunny H. Wong et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2019)

Article Cell Biology

Prevotella copri is associated with carboplatin-induced gut toxicity

Chaoheng Yu et al.

CELL DEATH & DISEASE (2019)

Article Pharmacology & Pharmacy

Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis

Cassandra Elise Gheorghe et al.

CURRENT OPINION IN PHARMACOLOGY (2019)

Article Multidisciplinary Sciences

Metabolomic adaptations and correlates of survival to immune checkpoint blockade

Haoxin Li et al.

NATURE COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

Healthy infants harbor intestinal bacteria that protect against food allergy

Taylor Feehley et al.

NATURE MEDICINE (2019)

Article Multidisciplinary Sciences

Dominant Role of the Gut Microbiota in Chemotherapy Induced Neuropathic Pain

Chandran Ramakrishna et al.

SCIENTIFIC REPORTS (2019)

Article Multidisciplinary Sciences

Bifidobacterium can mitigate intestinal immunopathology in the context of CTLA-4 blockade

Feng Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Multidisciplinary Sciences

Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors

Bertrand Routy et al.

SCIENCE (2018)

Article Integrative & Complementary Medicine

Anacardic acid inhibits pancreatic cancer cell growth, and potentiates chemotherapeutic effect by Chmp1A-ATM-p53 signaling pathway

Maiyon Park et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Review Pharmacology & Pharmacy

Drug-gut microbiota interactions: implications for neuropharmacology

Jacinta Walsh et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Review Endocrinology & Metabolism

The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective

Sofia Cussotto et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2018)

Article Oncology

The gut microbiota influences anticancer immunosurveillance and general health

Bertrand Routy et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2018)

Review Health Care Sciences & Services

Prophylactic probiotics for cancer therapy-induced diarrhoea: a meta-analysis

Hannah R. Wardill et al.

CURRENT OPINION IN SUPPORTIVE AND PALLIATIVE CARE (2018)

Article Multidisciplinary Sciences

Extensive impact of non-antibiotic drugs on human gut bacteria

Lisa Maier et al.

NATURE (2018)

Review Multidisciplinary Sciences

Microbial tryptophan catabolites in health and disease

Henrik M. Roager et al.

NATURE COMMUNICATIONS (2018)

Review Gastroenterology & Hepatology

A Systematic Review of the Efficacy and Safety of Fecal Microbiota Transplant for Clostridium difficile Infection in Immunocompromised Patients

Oluwaseun Shogbesan et al.

CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Biochemistry & Molecular Biology

Fecal microbiota transplantation for refractory immune checkpoint inhibitor-associated colitis

Yinghong Wang et al.

NATURE MEDICINE (2018)

Article Pharmacology & Pharmacy

The economic case for precision medicine

Sean P. Gavan et al.

EXPERT REVIEW OF PRECISION MEDICINE AND DRUG DEVELOPMENT (2018)

Review Cell Biology

Regulatory T cells in cancer immunotherapy

Atsushi Tanaka et al.

CELL RESEARCH (2017)

Article Neurosciences

Gut microbiota is critical for the induction of chemotherapy-induced pain

Shiqian Shen et al.

NATURE NEUROSCIENCE (2017)

Review Gastroenterology & Hepatology

Gut microbiota modulation of chemotherapy efficacy and toxicity

James L. Alexander et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

Review Multidisciplinary Sciences

Chemical transformation of xenobiotics by the human gut microbiota

Nitzan Koppel et al.

SCIENCE (2017)

Review Gastroenterology & Hepatology

Fusobacterium's link to colorectal neoplasia sequenced: A systematic review and future insights

Hisham Hussan et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Review Microbiology

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Patrice D. Cani et al.

FRONTIERS IN MICROBIOLOGY (2017)

Review Oncology

Discovery of IDO1 Inhibitors: From Bench to Bedside

George C. Prendergast et al.

CANCER RESEARCH (2017)

Review Biochemistry & Molecular Biology

Introduction to the human gut microbiota

Elizabeth Thursby et al.

BIOCHEMICAL JOURNAL (2017)

Article Gastroenterology & Hepatology

Proton pump inhibitors affect the gut microbiome

Floris Imhann et al.

Article Biochemistry & Molecular Biology

Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson's Disease

Timothy R. Sampson et al.

Article Biochemistry & Molecular Biology

Natural Product Anacardic Acid from Cashew Nut Shells Stimulates Neutrophil Extracellular Trap Production and Bactericidal Activity

Andrew Hollands et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Intestinal microbiome analyses identify melanoma patients at risk for checkpoint-blockade-induced colitis

Krista Dubin et al.

NATURE COMMUNICATIONS (2016)

Review Genetics & Heredity

Microbiome mediation of infections in the cancer setting

Ying Taur et al.

GENOME MEDICINE (2016)

Article Genetics & Heredity

Pretreatment gut microbiome predicts chemotherapy-related bloodstream infection

Emmanuel Montassier et al.

GENOME MEDICINE (2016)

Article Pharmacology & Pharmacy

Roles of UGT, P450, and Gut Microbiota in the Metabolism of Epacadostat in Humans

Jason Boer et al.

DRUG METABOLISM AND DISPOSITION (2016)

Review Behavioral Sciences

Serotonin, tryptophan metabolism and the brain-gut-microbiome axis

S. M. O'Mahony et al.

BEHAVIOURAL BRAIN RESEARCH (2015)

Article Microbiology

Evaluation of mucositis induced by irinotecan after microbial colonization in germ-free mice

Silvia H. S. P. Pedroso et al.

MICROBIOLOGY-SGM (2015)

Article Multidisciplinary Sciences

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

Marie Vetizou et al.

SCIENCE (2015)

Article Toxicology

Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

Felcy Pavithra Selwyn et al.

TOXICOLOGICAL SCIENCES (2015)

Review Biochemistry & Molecular Biology

Gut microbiome and anticancer immune response: really hot Sh☆t!

S. Viaud et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Gastroenterology & Hepatology

Bile acids and the gut microbiome

Jason M. Ridlon et al.

CURRENT OPINION IN GASTROENTEROLOGY (2014)

Article Psychology, Clinical

A Meta-Analysis of Cognitive Impairment Following Adult Cancer Chemotherapy

Oana C. Lindner et al.

NEUROPSYCHOLOGY (2014)

Review Biochemical Research Methods

Bacteria as vitamin suppliers to their host: a gut microbiota perspective

Jean Guy LeBlanc et al.

CURRENT OPINION IN BIOTECHNOLOGY (2013)

Article Multidisciplinary Sciences

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Yukihiro Furusawa et al.

NATURE (2013)

Review Multidisciplinary Sciences

Tumour heterogeneity in the clinic

Philippe L. Bedard et al.

NATURE (2013)

Article Medicine, General & Internal

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

W. H. Wilson Tang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2013)

Article Multidisciplinary Sciences

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

Sophie Viaud et al.

SCIENCE (2013)

Review Oncology

Selected Toxicities of Targeted Therapies: Presentation and Management

Christian Kollmannsberger et al.

SEMINARS IN ONCOLOGY (2013)

Review Neurosciences

Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour

John F. Cryan et al.

NATURE REVIEWS NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

The Inhibitory Receptor PD-1 Regulates IgA Selection and Bacterial Composition in the Gut

Shimpei Kawamoto et al.

SCIENCE (2012)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics of Tyrosine Kinase Inhibitors Focus on Pyrimidines, Pyridines and Pyrroles

Paola Di Gion et al.

CLINICAL PHARMACOKINETICS (2011)

Review Physiology

Gut Microbiota in Health and Disease

Inna Sekirov et al.

PHYSIOLOGICAL REVIEWS (2010)

Article Multidisciplinary Sciences

Alleviating Cancer Drug Toxicity by Inhibiting a Bacterial Enzyme

Bret D. Wallace et al.

SCIENCE (2010)

Article Oncology

Review: Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management

Alexander Stein et al.

Therapeutic Advances in Medical Oncology (2009)

Article Oncology

Diminished quality of life in patients with cancer correlates with tryptophan degradation

Katharina Schroecksnadel et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2007)

Article Multidisciplinary Sciences

Metagenomic analysis of the human distal gut microbiome

Steven R. Gill et al.

SCIENCE (2006)

Review Pharmacology & Pharmacy

Pharmacogenomics in cancer therapy: is host genome variability important?

WP Petros et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2004)