4.3 Review

Development of the gut microbiome in early life

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Review Pediatrics

Exploring functional metabolites in preterm infants

Victoria L. Renwick et al.

Summary: Metabolomics in preterm infants, particularly focusing on NEC and LOS, is a relatively new field with promising potential for identifying novel biomarkers and understanding disease processes. Studies have shown significant changes in metabolite profiles post-partum and throughout the first year of life, with associations between metabolites in serum, urine, and stool in health and disease. Further research is needed to identify specific metabolites associated with disease and the impact of microbially produced metabolites on immunoregulation in infants.

ACTA PAEDIATRICA (2022)

Article Gastroenterology & Hepatology

Human milk oligosaccharide DSLNT and gut microbiome in preterm infants predicts necrotising enterocolitis

Andrea C. Masi et al.

Summary: Necrotising enterocolitis (NEC) is a devastating intestinal disease primarily affecting preterm infants. The study found a significant lower concentration of a specific HMO in the breast milk of infants with NEC compared to controls. Combining HMO and metagenome data accurately classified 87.5% of infants as healthy or having NEC.
Article Immunology

Profound Pathogen-Specific Alterations in Intestinal Microbiota Composition Precede Late-Onset Sepsis in Preterm Infants: A Longitudinal, Multicenter, Case-Control Study

Sofia El Manouni El Hassani et al.

Summary: The study revealed that changes in intestinal microbiota composition occur before the onset of late-onset sepsis (LOS) in preterm infants, allowing for the identification of causative bacteria isolated later in blood culture. Predicting the onset of LOS has the potential to serve as an early noninvasive biomarker.

CLINICAL INFECTIOUS DISEASES (2021)

Review Biochemical Research Methods

Use of omic technologies in early life gastrointestinal health and disease: from bench to bedside

Lauren C. Beck et al.

Summary: The gut microbiome plays a fundamental role in host health, and advancements in high-throughput technologies have enabled deeper profiling of GI diseases. Multi-omic technologies help unravel the complexities of diseases, aiding in biomarker discovery and therapeutic development.

EXPERT REVIEW OF PROTEOMICS (2021)

Article Biochemistry & Molecular Biology

Bifidobacteria-mediated immune system imprinting early in life

Bethany M. Henrick et al.

Summary: Early immune-microbe interactions play a role in the development of allergies, asthma, and inflammatory diseases. Breastfeeding promotes healthier immune-microbe relationships by providing necessary nutrients to beneficial microbes. The lack of bifidobacteria and genes required for HMO utilization can lead to systemic inflammation and immune dysregulation in early life.
Article Nutrition & Dietetics

Impact of Postnatal Antibiotics and Parenteral Nutrition on the Gut Microbiota in Preterm Infants During Early Life

Jie Jia et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2020)

Article Evolutionary Biology

The impact of early life antibiotic use on atopic and metabolic disorders Meta-analyses of recent insights

Semeh Bejaoui et al.

EVOLUTION MEDICINE AND PUBLIC HEALTH (2020)

Review Immunology

The Preterm Gut Microbiota: An Inconspicuous Challenge in Nutritional Neonatal Care

Jannie G. E. Henderickx et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2019)

Article Multidisciplinary Sciences

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Guillermo J. Ares et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

Article Pediatrics

Antibiotic exposure and development of necrotizing enterocolitis in very preterm neonates

Rana Esmaeilizand et al.

PAEDIATRICS & CHILD HEALTH (2018)

Review Gastroenterology & Hepatology

Microfluidic Organ-on-a-Chip Models of Human Intestine

Amir Bein et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Biochemical Research Methods

Metaproteomics reveals functional differences in intestinal microbiota development of preterm infants

Romy D. Zwittink et al.

MOLECULAR & CELLULAR PROTEOMICS (2017)

Review Cell Biology

Gut microbiota: A player in aging and a target for anti-aging intervention

Alexander M. Vaiserman et al.

AGEING RESEARCH REVIEWS (2017)

Article Gastroenterology & Hepatology

Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model

Yueyue Yu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

Analysis of the microbiome: Advantages of whole genome shotgun versus 16S amplicon sequencing

Ravi Ranjan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Review Gastroenterology & Hepatology

Necrotizing enterocolitis: new insights into pathogenesis and mechanisms

Diego F. Nino et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2016)

Article Biochemistry & Molecular Biology

Human Genetics Shape the Gut Microbiome

Julia K. Goodrich et al.

Article Multidisciplinary Sciences

Patterned progression of bacterial populations in the premature infant gut

Patricio S. La Rosa et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Cell Biology

Exploring host-microbiota interactions in animal models and humans

Aleksandar D. Kostic et al.

GENES & DEVELOPMENT (2013)

Review Microbiology

The gut microbiota - masters of host development and physiology

Felix Sommer et al.

NATURE REVIEWS MICROBIOLOGY (2013)