相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report
Sizhao Lu et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)
Autophagy drives fibroblast senescence through MTORC2 regulation
Monique Bernard et al.
AUTOPHAGY (2020)
Downregulation of PTEN mediates bleomycin-induced premature senescence in lung cancer cells by suppressing autophagy
Xiaoyan Sai et al.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)
Senolytic drugs: from discovery to translation
J. L. Kirkland et al.
JOURNAL OF INTERNAL MEDICINE (2020)
Nifedipine-induced AMPK activation alleviates senescence by increasing autophagy and suppressing of Ca2+ levels in vascular smooth muscle cells
Seul Gi Kim et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2020)
PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation
Ting Qiu et al.
AGING-US (2019)
Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation
Yaqiong Tian et al.
AGING CELL (2019)
Fisetin, via CKIP-1/REGγ, limits oxidized LDL-induced lipid accumulation and senescence in RAW264.7 macrophage-derived foam cells
QingLing Jia et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2019)
mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53
Seung Hee Jung et al.
ONCOGENE (2019)
Interaction between mTOR pathway inhibition and autophagy induction attenuates adriamycin-induced vascular smooth muscle cell senescence through decreased expressions of p53/p21/p16
Jin Young Sung et al.
EXPERIMENTAL GERONTOLOGY (2018)
mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway
Han-wei Yang et al.
ACTA PHARMACOLOGICA SINICA (2018)
PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo
Maxime Parisotto et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2018)
Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration
Sandeep Singh et al.
LIFE SCIENCES (2018)
Fisetin is a senotherapeutic that extends health and lifespan
Matthew J. Yousefzadeh et al.
EBIOMEDICINE (2018)
Fisetin Regulates Nrf2 Expression and the Inflammation-Related Signaling Pathway to Prevent UVB-Induced Skin Damage in Hairless Mice
Po-Yuan Wu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
The Clinical Potential of Senolytic Drugs
James L. Kirkland et al.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY (2017)
Cellular Senescence: A Translational Perspective
James L. Kirkland et al.
EBIOMEDICINE (2017)
Rictor/mTORC2 deficiency enhances keratinocyte stress tolerance via mitohormesis
Beatrice Tassone et al.
CELL DEATH AND DIFFERENTIATION (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
New agents that target senescent cells: the flavone, fisetin, and the BCL-XL inhibitors, A1331852 and A1155463
Yi Zhu et al.
AGING-US (2017)
Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice
Emma L. Baar et al.
AGING CELL (2016)
Context-dependent effects of cellular senescence in cancer development
Pacome Lecot et al.
BRITISH JOURNAL OF CANCER (2016)
Genistein-induced LKB1-AMPK activation inhibits senescence of VSMC through autophagy induction
Kyung Young Lee et al.
VASCULAR PHARMACOLOGY (2016)
The underlying mechanism of proinflammatory NF-κB activation by the mTORC2/Akt/IKKα pathway during skin aging
Yeon Ja Choi et al.
ONCOTARGET (2016)
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
Yi Zhu et al.
AGING CELL (2015)
Effects of PTEN on the longevity of cultured human umbilical vein endothelial cells: The role of antioxidants
Izak S. Tait et al.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015)
Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction
Richard A. Miller et al.
AGING CELL (2014)
ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis
Yuyan Xiong et al.
AUTOPHAGY (2014)
PTEN, Longevity and Age-Related Diseases
Izak S. Tait et al.
BIOMEDICINES (2013)
Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition off superoxide production
Sun Ah Ham et al.
BIOCHEMICAL JOURNAL (2012)
Pten Positively Regulates Brown Adipose Function, Energy Expenditure, and Longevity
Ana Ortega-Molina et al.
CELL METABOLISM (2012)
mTOR Complex 2 Activation by Reconstituted High-Density Lipoprotein Prevents Senescence in Circulating Angiogenic Cells
Xianrong Guo et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
PTEN status switches cell fate between premature senescence and apoptosis in glioma exposed to ionizing radiation
J-J Lee et al.
CELL DEATH AND DIFFERENTIATION (2011)
PPARδ Coordinates Angiotensin II-induced Senescence in Vascular Smooth Muscle Cells through PTEN-mediated Inhibition of Superoxide Generation
Hyo Jung Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
Oncogenic EGFR Signaling Activates an mTORC2-NF-κB Pathway That Promotes Chemotherapy Resistance
Kazuhiro Tanaka et al.
CANCER DISCOVERY (2011)
TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
Jeremy Copp et al.
CANCER RESEARCH (2009)
Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans
Alexander A. Soukas et al.
GENES & DEVELOPMENT (2009)
mTOR signaling at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2009)
Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo
J. A. Ewald et al.
BRITISH JOURNAL OF CANCER (2008)
A chemotherapy-associated senescence bystander effect in breast cancer cells
Xu Di et al.
CANCER BIOLOGY & THERAPY (2008)
The mammalian target of rapamycin-signaling pathway in regulating metabolism and growth1,2
X. Yang et al.
JOURNAL OF ANIMAL SCIENCE (2007)
Fisetin, an inhibitor of cyclin-dependent kinase 6, down-regulates nuclear factor-κB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of TAK-1 and receptor-interacting protein-regulated IκBα kinase activation
Bokyung Sung et al.
MOLECULAR PHARMACOLOGY (2007)
PTEN function in normal and neoplastic growth
Lionel M. L. Chow et al.
CANCER LETTERS (2006)
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Omer H. Yilmaz et al.
NATURE (2006)
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
Jiwang Zhang et al.
NATURE (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
The identification of senescence-specific genes during the induction of senescence in prostate cancer cells
SR Schwarze et al.
NEOPLASIA (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
JG Wood et al.
NATURE (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
P Kapahi et al.
CURRENT BIOLOGY (2004)
Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises Part I: Aging arteries: A set up for vascular disease
EG Lakatta et al.
CIRCULATION (2003)
分享论文
