期刊
EXPERIMENTAL DERMATOLOGY
卷 31, 期 4, 页码 586-593出版社
WILEY
DOI: 10.1111/exd.14493
关键词
genetics; mast cells; photobiology; photodermatoses; photosensitivity disorders; urticaria
类别
资金
- National Institute for Health Research Clinical Training Fellowship
- Medical Research Council Clinical Research Training Fellowship [MR/V006746/1]
- British Skin Foundation [027/BSFBPG/20]
- British Photodermatology Group
Solar urticaria is a rare photodermatosis triggered by specific wavelengths of solar radiation, leading to rapid development of cutaneous symptoms. While a 'photoallergy' model has been proposed, recent observations challenge this explanation and highlight the need for a reevaluation of the disease pathogenesis in the context of contemporary scientific understanding.
Solar urticaria is a rare, immunologically mediated photodermatosis in which activation of cutaneous mast cells is triggered by specific wavelengths of solar electromagnetic radiation. This manifests clinically as the rapid development of cutaneous itch, erythema and wheal formation after several minutes of sun exposure. Disease mechanisms in solar urticaria remain incompletely elucidated and there have been few recent investigations of its pathobiology. Historic passive transfer experiments performed during the twentieth century provide support for a 'photoallergy' model of disease pathogenesis, wherein molecular alteration of a putative chromophore by solar electromagnetic radiation produces mast cell activation via an IgE-dependent mechanism. However, this model does not account for several observations made during passive transfer experiments nor does it explain a range of subsequent clinical and photobiological observations made in solar urticaria patients. Furthermore, increased understanding of the molecular dynamics underpinning cutaneous mast cell responses highlights the need to reformulate our understanding of solar urticaria pathogenesis in the context of this contemporary scientific landscape. In this review, we discuss the current understanding of solar urticaria pathogenesis and, by incorporating recent scientific and clinical observations, develop new hypotheses to drive future investigation into this intriguing disorder.
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