期刊
EXPERIMENTAL CELL RESEARCH
卷 407, 期 2, 页码 -出版社
ELSEVIER INC
DOI: 10.1016/j.yexcr.2021.112808
关键词
CD8 T cell; Glioma; T follicular regulatory cell
资金
- Project of Clinical Outstanding Clinical Discipline Construction in Shanghai Pudong New Area [PWYgy2018-07]
- Project of Shanghai Municipality Key Medical Specialties Construction [ZK2019C08]
- Leading Talent Training in Shanghai Pudong New Area Health System [PWRl2018-08]
The study found significantly elevated levels of Tfr cells in CD4 T cells infiltrating glioma tumors, and these cells can significantly suppress the proliferation and cytotoxic capacity of CD8 T cells toward glioma cells.
Regulatory T (Treg) cells are thought to contribute to tumor pathogenesis by suppressing tumor immuno-surveillance and antitumor immunity. T follicular regulatory (Tfr) cells are a recently characterized Treg subset that expresses both the Treg transcription factor (TF) Foxp3 and the T follicular helper (Tfh) TF Bcl-6. The role of Tfr cells in glioma patients remains unclear. In this study, we found that the level of Tfr cells, identified as Foxp3(+)Bcl-6(+) CD4 T cells, was significantly elevated in tumor-infiltrating CD4 T cells from resected glioma tumors. Both Tfr cells and Treg cells significantly suppressed the proliferation and the cytotoxic capacity of CD8 T cells toward glioma tumor cells, and the suppression was positively associated with the proportion of Tfr cells and Treg cells, respectively. Tfr and Treg cells from glioma tumor samples demonstrated higher suppression potency than those from healthy blood samples and glioma blood samples. Interestingly, canonical CXCR5(-) Treg cells could suppress both CXCR5(+) and CXCR5(-) CD8 T cells, albeit with stronger potency toward CXCR5(-) CD8 T cells. However, Tfr cells presented much higher suppression potency toward CXCR5(+) CD8 T cells, whereas CXCR5(+) CD8 T cells are a potent CD8 T cell subset previously described to have antiviral and antitumor roles. Overall, these data indicate that Tfr cells are enriched in glioma tumors and have suppressive capacity toward CD8 T cell-mediated effector functions.
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