4.7 Review

Organoids as host models for infection biology - a review of methods

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Gastroenterology & Hepatology

Location-specific cell identity rather than exposure to GI microbiota defines many innate immune signalling cascades in the gut epithelium

Ozge Kayisoglu et al.

Summary: The study demonstrates extensive spatial organization of innate immune signaling components along the cephalocaudal axis in the GI tract. This organization is largely determined before birth and independent of exposure to commensal gut microbiota. Gastric epithelial organoids can sense LPS from both the basal and apical sides.
Review Biotechnology & Applied Microbiology

Organs-on-chips: into the next decade

Lucie A. Low et al.

Summary: OoCs, also known as microphysiological systems or 'tissue chips', have the potential to be informative at multiple stages of drug discovery and development, providing insights into normal human organ function and disease pathophysiology, as well as predicting the safety and efficacy of investigational drugs in humans. The field of OoCs has seen significant advances in recent years, but there are still challenges and opportunities that need to be addressed to fully realize their potential for translational research.

NATURE REVIEWS DRUG DISCOVERY (2021)

Review Chemistry, Physical

Rethinking organoid technology through bioengineering

Elena Garreta et al.

Summary: Significant progress has been made in the differentiation of human pluripotent stem cells and the development of organoids. The convergence of stem cell biology and bioengineering allows for controlled stimuli to be provided to the system. Engineering solutions are emphasized to control the self-organization and functionality of stem cell-derived organoids.

NATURE MATERIALS (2021)

Article Microbiology

Ephrin receptor A2, the epithelial receptor for Epstein-Barr virus entry, is not available for efficient infection in human gastric organoids

Nina Wallaschek et al.

Summary: The study reveals that EBV infection in gastric cancer is associated with partial changes in the Ephrin receptor A2 (EPHA2) of gastric epithelial cells. In healthy gastric epithelium, this receptor is confined to cell-cell junctions, making it difficult for EBV infection, while it is expressed normally in cancer cells, making them susceptible to infection.

PLOS PATHOGENS (2021)

Review Biotechnology & Applied Microbiology

Leveling Up Hydrogels: Hybrid Systems in Tissue Engineering

Sara C. Neves et al.

TRENDS IN BIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Mutational signature in colorectal cancer caused by genotoxic pks+E. coli

Cayetano Pleguezuelos-Manzano et al.

NATURE (2020)

Review Engineering, Biomedical

Decellularized tissues as platforms for in vitro modeling of healthy and diseased tissues

Michaela W. McCrary et al.

ACTA BIOMATERIALIA (2020)

Article Multidisciplinary Sciences

Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease

Steven J. Mileto et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

Linlin Bao et al.

NATURE (2020)

Review Cell Biology

Human organoids: model systems for human biology and medicine

Jihoon Kim et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Mikhail Nikolaev et al.

NATURE (2020)

Article Multidisciplinary Sciences

Progenitor identification and SARS-CoV-2 infection in human distal lung organoids

Ameen A. Salahudeen et al.

NATURE (2020)

Review Immunology

Organoids in immunological research

Yotam E. Bar-Ephraim et al.

NATURE REVIEWS IMMUNOLOGY (2020)

Article Biotechnology & Applied Microbiology

Tubuloids derived from human adult kidney and urine for personalized disease modeling

Frans Schutgens et al.

NATURE BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Chronic Chlamydia infection in human organoids increases stemness and promotes age-dependent CpG methylation

Mirjana Kessler et al.

NATURE COMMUNICATIONS (2019)

Article Engineering, Biomedical

A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip

Sasan Jalili-Firoozinezhad et al.

NATURE BIOMEDICAL ENGINEERING (2019)

Article Cell Biology

Disease modelling in human organoids

Madeline A. Lancaster et al.

DISEASE MODELS & MECHANISMS (2019)

Review Multidisciplinary Sciences

Organoids by design

Takanori Takebe et al.

SCIENCE (2019)

Article Multidisciplinary Sciences

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection

Devanjali Dutta et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2019)

Article Biochemistry & Molecular Biology

Long-term expanding human airway organoids for disease modeling

Norman Sachs et al.

EMBO JOURNAL (2019)

Review Gastroenterology & Hepatology

Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids

Masayuki Fujii et al.

GASTROENTEROLOGY (2019)

Article Immunology

Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model

Sridevi Ranganathan et al.

INFECTION AND IMMUNITY (2019)

Review Biotechnology & Applied Microbiology

Engineering Organoid Vascularization

Sergei Grebenyuk et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Article Multidisciplinary Sciences

Patient-derived organoids model treatment response of metastatic gastrointestinal cancers

Georgios Vlachogiannis et al.

SCIENCE (2018)

Article Multidisciplinary Sciences

A urine-dependent human urothelial organoid offers a potential alternative to rodent models of infection

Harry Horsley et al.

SCIENTIFIC REPORTS (2018)

Article Multidisciplinary Sciences

Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells

Jessica L. Forbester et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Gastroenterology & Hepatology

A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology

Ian A. Williamson et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Biochemistry & Molecular Biology

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system

Michael J. Workman et al.

NATURE MEDICINE (2017)

Article Veterinary Sciences

Crosstalk between H9N2 avian influenza virus and crypt-derived intestinal organoids

Lulu Huang et al.

VETERINARY RESEARCH (2017)

Article Biochemistry & Molecular Biology

Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure

Xuyu Qian et al.

Review Developmental Biology

Modeling infectious diseases and host-microbe interactions in gastrointestinal organoids

Sina Bartfeld

DEVELOPMENTAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Frizzled proteins are colonic epithelial receptors for C. difficile toxin B

Liang Tao et al.

NATURE (2016)

Article Multidisciplinary Sciences

Tissue-specific mutation accumulation in human adult stem cells during life

Francis Blokzijl et al.

NATURE (2016)

Review Cell Biology

Pluripotent stem cells in disease modelling and drug discovery

Yishai Avior et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Article Multidisciplinary Sciences

Replication of human noroviruses in stem cell-derived human enteroids

Khalil Ettayebi et al.

SCIENCE (2016)

Article Multidisciplinary Sciences

Zika virus impairs growth in human neurospheres and brain organoids

Patricia P. Garcez et al.

SCIENCE (2016)

Article Cell & Tissue Engineering

Development of an Advanced Primary Human In Vitro Model of the Small Intestine

Matthias Schweinlin et al.

TISSUE ENGINEERING PART C-METHODS (2016)

Article Multidisciplinary Sciences

A microfluidics-based in vitro model of the gastrointestinal human-microbe interface

Pranjul Shah et al.

NATURE COMMUNICATIONS (2016)

Article Gastroenterology & Hepatology

Human Clostridium difficile infection: altered mucus production and composition

Melinda A. Engevik et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2015)

Article Biochemistry & Molecular Biology

Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver

Meritxell Huch et al.

Article Biochemistry & Molecular Biology

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

Marc van de Wetering et al.

Article Gastroenterology & Hepatology

In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection

Sina Bartfeld et al.

GASTROENTEROLOGY (2015)

Article Multidisciplinary Sciences

Organoids as Model for Infectious Diseases: Culture of Human and Murine Stomach Organoids and Microinjection of Helicobacter Pylori

Sina Bartfeld et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Article Biochemical Research Methods

A biomimetic multicellular model of the airways using primary human cells

Katelyn L. Sellgren et al.

LAB ON A CHIP (2014)

Article Multidisciplinary Sciences

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

Kyle W. McCracken et al.

NATURE (2014)

Editorial Material Multidisciplinary Sciences

Make mouse studies work

Steve Perrin

NATURE (2014)

Article Biochemistry & Molecular Biology

Oncogenic transformation of diverse gastrointestinal tissues in primary organoid culture

Xingnan Li et al.

NATURE MEDICINE (2014)

Review Multidisciplinary Sciences

Organogenesis in a dish: Modeling development and disease using organoid technologies

Madeline A. Lancaster et al.

SCIENCE (2014)

Article Biochemistry & Molecular Biology

A functional CFTR assay using primary cystic fibrosis intestinal organoids

Johanna F. Dekkers et al.

NATURE MEDICINE (2013)