期刊
EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY
卷 30, 期 6, 页码 973-982出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/pha0000523
关键词
electronic nicotine delivery systems; abuse liability; progressive ratio task; nicotine concentration; device power
资金
- National Institute on Drug Abuse of the National Institutes of Health (NIH)
- Center for Tobacco Products of the U.S. Food and Drug Administration (FDA) [U54DA036105]
The study suggests that limiting liquid nicotine concentration in electronic nicotine delivery systems without regulating device power may not effectively reduce abuse liability, as users may increase device power to compensate for low nicotine concentration.
Public Health Significance Several countries have current policy in place or are considering limiting the nicotine concentration found in the liquid solution of electronic nicotine delivery systems (ENDS) to decrease their abuse liability. This study suggests that limiting liquid nicotine concentration without regulating ENDS device power may be insufficient as abuse liability for low nicotine ENDS increases if paired with greater device power. Open-system electronic nicotine delivery systems (ENDS) permit modifications to device characteristics such as power, potentially increasing nicotine and toxicant delivery. Limiting liquid nicotine concentration may carry unintended consequences by prompting users to increase device power to increase nicotine delivery. This study examined the abuse liability of ENDS across nicotine concentration and power settings. In a clinical laboratory study, n = 19 exclusive ENDS users and n = 13 dual ENDS/cigarette users, aged 21-55 completed four Latin-square ordered conditions that varied by liquid nicotine concentration (10 mg/ml [low], 30 mg/ml [high]) and device power (15 watts [low], 30 watts [high]), that were followed by a fifth own brand (OB) condition. A progressive ratio task (PRT) using bar presses to earn ENDS puffs was used to assess abuse liability and compare between conditions using mixed effects linear regressions. The low nicotine/high watt condition was associated with a significantly higher number of bar presses and puffs earned relative to the OB ENDS, high nicotine/high watt, and high nicotine/low watt conditions (p < .05). Findings appeared to be driven largely by exclusive ENDS users; most comparisons were not significant among dual users. Participants worked significantly harder for puffs of low nicotine/high watt ENDS, highlighting previous findings that suggest limiting liquid nicotine concentration without addressing power settings may be insufficient to reduce the abuse liability of ENDS.
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