Epidemiological and clinical insights from SARS-CoV-2 RT-PCR crossing threshold values, France, January to November 2020

Article Multidisciplinary Sciences

The coding capacity of SARS-CoV-2

Yaara Finkel et al.

Summary: A high-resolution map of coding regions in the SARS-CoV-2 genome enables the identification of 23 unannotated open reading frames and quantification of the expression of canonical viral open reading frames.

NATURE (2021)

添加到收藏夹

Article Infectious Diseases

Predicting COVID-19 incidence in French hospitals using human contact network analytics

Christian Selinger et al.

Summary: Researchers developed predictive models of hospital incidence between July 2020 and April 2021 by incorporating human contact network analytics, which significantly improved predictions at both the national and subnational levels by more than 50%. This innovative use of network analytics from colocalization data opens new possibilities for epidemic forecasting and public health.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Modeling SARS-CoV-2 viral kinetics and association with mortality in hospitalized patients from the French COVID cohort

Nadege Neant et al.

Summary: The study found that age ≥ 65 years, male gender, and chronic pulmonary disease were risk factors associated with mortality from COVID-19. Viral dynamics post-infection independently predicted mortality risk, and pharmacological interventions could shorten time to viral clearance, reducing mortality rates.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7

Nicholas G. Davies et al.

Summary: Studies have shown that the SARS-CoV-2 B.1.1.7 lineage is more transmissible and may cause more severe illness compared to pre-existing variants.

NATURE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil

Nuno R. Faria et al.

Summary: A new variant of concern, P.1, with 17 mutations including three spike protein mutations associated with increased binding to human ACE2 receptors, emerged in Manaus, Brazil between November 2020 and January 2021. Molecular analysis suggests P.1 may be 1.7- to 2.4-fold more transmissible and that previous infection may provide 54 to 79% protection against P.1 infection compared to other lineages. Enhanced global genomic surveillance of such variants is crucial for pandemic response.

SCIENCE (2021)

添加到收藏夹

Article Infectious Diseases

Characterisation of vaccine breakthrough infections of SARS-CoV-2 Delta and Alpha variants and within-host viral load dynamics in the community, France, June to July 2021

Francois Blanquart et al.

EUROSURVEILLANCE (2021)

添加到收藏夹

Article Infectious Diseases

Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021

Samuel Alizon et al.

Summary: The study found rapid growth of the Delta variant in three metropolitan regions of France, with an estimated transmission advantage of +79% compared with the Alpha variant. The coming weeks will be crucial, as the magnitude of the estimated transmission advantage of the Delta variant could pose a major challenge for public health authorities.

EUROSURVEILLANCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Spatiotemporal invasion dynamics of SARS-CoV-2 lineage B.1.1.7 emergence

Moritz U. G. Kraemer et al.

Summary: Understanding the spatial invasion dynamics of the B.1.1.7 lineage, researchers found a multistage process with early growth rates linked to human mobility and asymmetric lineage export from dominant source locations. Additionally, they explored how the spread of B.1.1.7 was influenced by nonpharmaceutical interventions and spatial variation in previous attack rates. The study emphasizes the importance of considering behavioral and epidemiological contexts in accurately interpreting the growth rates of emerging variants of concern.

SCIENCE (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Estimating epidemiologic dynamics from cross-sectional viral load distributions

James A. Hay et al.

Summary: Population distribution of viral loads changes during an epidemic, and Ct values from random samples can improve estimates of an epidemic's trajectory. Combining data from multiple samples enhances the precision and robustness of estimation. These methods can be applied to real-time estimates of epidemic trajectories for outbreak management and response.

SCIENCE (2021)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

SARS-CoV-2 viral RNA levels are not 'viral load'

Yannis Michalakis et al.

Summary: Ct values are commonly used as proxies of SARS-CoV-2 viral load, but equating them may lead to flawed conclusions, as it is unknown whether Ct variation reflects viral load or gene expression.

TRENDS IN MICROBIOLOGY (2021)

添加到收藏夹

Article Infectious Diseases

Memory is key in capturing COVID-19 epidemiological dynamics

Mircea T. Sofonea et al.

Summary: The study developed a parsimonious discrete-time model to analyze the spread of COVID-19 in France, estimating key epidemiological parameters and the impact of lockdown implementation delay. By incorporating memory effects into the model, the accuracy of fitting epidemiological data was greatly improved.

EPIDEMICS (2021)

添加到收藏夹

Article Biology

Ct threshold values, a proxy for viral load in community SARS-CoV-2 cases, demonstrate wide variation across populations and over time

A Sarah Walker et al.

eLife (2021)

添加到收藏夹

Article Public, Environmental & Occupational Health

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021

Catherine M. Brown et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

添加到收藏夹

Article Immunology

Detecting Rapid Spread of SARS- CoV-2 Variants, France, January 26-February 16, 2021

Stephanie Haim-Boukobza et al.

Summary: The variants of severe acute respiratory syndrome coronavirus 2 found in France during the study demonstrated a higher transmission advantage and more advanced spread than anticipated, raising concerns about the control of coronavirus disease epidemics.

EMERGING INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Multidisciplinary Sciences