4.7 Article

The effect of gadolinium-based contrast-agents on automated brain atrophy measurements by FreeSurfer in patients with multiple sclerosis

期刊

EUROPEAN RADIOLOGY
卷 32, 期 5, 页码 3576-3587

出版社

SPRINGER
DOI: 10.1007/s00330-021-08405-8

关键词

Multiple sclerosis; Magnetic resonance imaging; Gadolinium; Atrophy; Grey matter

资金

  1. University of Bergen (Haukeland University Hospital)
  2. Western Norway Regional Health Authority [912020]
  3. Dutch MS Research Foundation [MS 18-358f, 446002506]
  4. ZonMW [446002506]
  5. Health Holland Life Sciences Health [LSHM19053]
  6. Neuro-SysMed at Haukeland University Hospital
  7. University of Bergen from the Research Council of Norway [288164]
  8. National Institute for Health Research (NIHR) biomedical research centre at University College London Hospitals NHS Foundation Trust (UCLH)

向作者/读者索取更多资源

This study aimed to determine whether reliable brain atrophy measures can be obtained from post-contrast 3D T1-weighted images using FreeSurfer in patients with multiple sclerosis (MS). The results showed excellent consistency between measures obtained from pre- and post-contrast images, suggesting the possibility of extracting reliable brain atrophy measurements. However, there were systematic differences in absolute values between pre- and post-contrast images, indicating the need for further investigation into potential systematic effects.
Objective To determine whether reliable brain atrophy measures can be obtained from post-contrast 3D T1-weighted images in patients with multiple sclerosis (MS) using FreeSurfer. Methods Twenty-two patients with MS were included, in which 3D T1-weighted MR images were obtained during the same scanner visit, with the same acquisition protocol, before and after administration of gadolinium-based contrast agents (GBCAs). Two FreeSurfer versions (v.6.0.1 and v.7.1.1.) were applied to calculate grey matter (GM) and white matter (WM) volumes and global and regional cortical thickness. The consistency between measures obtained in pre- and post-contrast images was assessed by intra-class correlation coefficient (ICC), the difference was investigated by paired t-tests, and the mean percentage increase or decrease was calculated for total WM and GM matter volume, total deep GM and thalamus volume, and mean cortical thickness. Results Good to excellent reliability was found between all investigated measures, with ICC ranging from 0.926 to 0.996, all p values < 0.001. GM volumes and cortical thickness measurements were significantly higher in post-contrast images by 3.1 to 17.4%, while total WM volume decreased significantly by 1.7% (all p values < 0.001). Conclusion The consistency between values obtained from pre- and post-contrast images was excellent, suggesting it may be possible to extract reliable brain atrophy measurements from T1-weighted images acquired after administration of GBCAs, using FreeSurfer. However, absolute values were systematically different between pre- and post-contrast images, meaning that such images should not be compared directly. Potential systematic effects, possibly dependent on GBCA dose or the delay time after contrast injection, should be investigated.

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