期刊
EUROPEAN RADIOLOGY
卷 32, 期 6, 页码 3726-3733出版社
SPRINGER
DOI: 10.1007/s00330-021-08516-2
关键词
Attention-deficit; hyperactivity disorder; Magnetic resonance imaging; Iron deficiency
资金
- National Natural Science Foundation of China [82001439]
- Medical Scientific Research Foundation of Guangdong Province [A2020327]
This study used quantitative susceptibility mapping (QSM) technique to compare the iron deposition in the whole brain between attention-deficit/hyperactivity disorder (ADHD) patients and typically developing (TD) children. The results showed iron deficiency in several brain regions of children with ADHD, including bilateral striatums, anterior cingulum, olfactory gyrus, and right lingual gyri. Further correlation analysis revealed a positive correlation between the severity of symptoms and the left anterior cingulum.
Objectives To quantitatively measure and compare the whole-brain iron deposition between attention-deficit/hyperactivity disorder (ADHD) patients and typically developing (TD) children using the quantitative susceptibility mapping (QSM) technique. Methods This study was approved by the institutional review board of our institution (No. [2019]328). Fifty-one patients between 6 and 14 years with clinical diagnosis of ADHD and 51 age- and gender-paired TD children were enrolled. For each participant, the 3D T1 and multi-echo GRE sequence were performed to acquire the whole-brain data with 3.0-T MRI. The QSM maps were calculated using STISuite toolbox. After normalizing the QSM images to MNI space, the voxel-based analysis was used to compare the iron content between the two groups. Pearson's correlation test was used to assess the associations between the iron content and the score of the tablet-PC-based cancellation test, which was done to evaluate the attention concentration level. Results Iron deficiency was observed in several brain regions in children with ADHD, including bilateral striatums, anterior cingulum, olfactory gyrus, and right lingual gyri. In further correlation analysis, the left anterior cingulum was found to show positive correlation with the symptom severity (r = 0.326, p < 0.05). Conclusions Our study demonstrated that the iron deficiency in several brain regions might be related with ADHD, which might be valuable for further studies. And QSM might have the potential efficacy in the auxiliary diagnosis of ADHD.
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