Diagnostic Accuracy of 2-[18F]FDG-PET and whole-body DW-MRI for the detection of bone marrow metastases in children and young adults

Objectives To compare the diagnostic accuracy of 2-[F-18]fluoro-2-deoxy-d-glucose-enhanced positron emission tomography (2-[F-18]FDG-PET) and diffusion-weighted magnetic resonance imaging (DW-MRI) for the detection of bone marrow metastases in children and young adults with solid malignancies. Methods In this cross-sectional single-center institutional review board-approved study, we investigated twenty-three children and young adults (mean age, 16.8 years +/- 5.1 [standard deviation]; age range, 7-25 years; 16 males, 7 females) with 925 bone marrow metastases who underwent 66 simultaneous 2-[F-18]FDG-PET and DW-MRI scans including 23 baseline scans and 43 follow-up scans after chemotherapy between May 2015 and July 2020. Four reviewers evaluated all foci of bone marrow metastasis on 2-[F-18]FDG-PET and DW-MRI to assess concordance and measured the tumor-to-bone marrow contrast. Results were assessed with a one-sample Wilcoxon test and generalized estimation equation. Bone marrow biopsies and follow-up imaging served as the standard of reference. Results The reviewers detected 884 (884/925, 95.5%) bone marrow metastases on 2-[F-18]FDG-PET and 893 (893/925, 96.5%) bone marrow metastases on DW-MRI. We found different blind spots for 2-[F-18]FDG-PET and MRI: 2-[F-18]FDG-PET missed subcentimeter lesions while DW-MRI missed lesions in small bones. Sensitivity and specificity were 91.0% and 100% for F-18-FDG-PET, 89.1% and 100.0% for DW-MRI, and 100.0% and 100.0% for combined modalities, respectively. The diagnostic accuracy of combined 2-[F-18]FDG-PET/MRI (100.0%) was significantly higher compared to either 2-[F-18]FDG-PET (96.9%, p < 0.001) or DW-MRI (96.3%, p < 0.001). Conclusions Both 2-[F-18]FDG-PET and DW-MRI can miss bone marrow metastases. The combination of both imaging techniques detected significantly more lesions than either technique alone.

Automated summary

This study compares the diagnostic accuracy of 2-[F-18]fluoro-2-deoxy-d-glucose-enhanced positron emission tomography (2-[F-18]FDG-PET) and diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of bone marrow metastases in children and young adults with solid malignancies. The results show that both 2-[F-18]FDG-PET and DW-MRI can miss bone marrow metastases, but the combination of both techniques can significantly improve lesion detection.