Developing a new photoluminescent, nanoporous, and biocompatible glycodendrimer for smart hepatic cancer treatment

In this work for the first time, a novel photoluminescent glycodendrimer was fabricated through the growth of polyamidoamine dendrimer (PAMAM-G3) on the zirconium-based nano metal-organic framework (Zr-MOF) (UiO-66-NH2-PAMAM). Subsequently, the as-synthesized UiO-66-NH2-PAMAM was functionalized with D-galactose (D-Gal) to increase the biocompatibility and induce targeted drug delivery for obtained system (UiO-66-NH2-PAMAM-Gal). The UiO-66-NH2-PAMAM-Gal was evaluated using several characterization techniques. Nitrogen adsorption-desorption test obtained mean pore diameter of UiO-66-NH2-PAMAM-Gal similar to 5.87 nm. Owing to the favorable features, UiO-66-NH2-PAMAM-Gal provided respectively 71.4% and 56.0% of drug loading for both doxorubicin (DOX) and curcumin (CUR), and pH-controlled release profiles. Cell viability assay approved that the functionalization with D-Gal enhanced the biocompatibility as well as achieved targeted hepatic cancer treatment. In addition, the 4',6-diamidino-2-phenylindole (DAPI) staining and cell cycle showed that the UiO-66-NH2-PAMAM-Gal could uptake within cancer cells to obtain improved cancer treatment efficacy. In comparison to the free PAMAM dendrimers or UiO-66-NH2 based drug carriers the targeted drug delivery capability combined with the bioimaging potential of UiO-66-NH2-PAMAM-Gal could be valuable advantages, so, the results declared that the UiO-66-NH2-PAMAM-Gal could act as an optimistic multifunctional candidate for both bioimaging and targeted tumor therapy.

Automated summary

A novel photoluminescent glycodendrimer was fabricated by growing polyamidoamine dendrimer on a zirconium-based nano metal-organic framework, followed by functionalization with D-galactose. This system showed promising drug loading and controlled release capabilities, enhanced biocompatibility, and targeted hepatic cancer treatment efficacy. The multifunctional UiO-66-NH2-PAMAM-Gal could be a valuable candidate for bioimaging and targeted tumor therapy.