Functional role of crosslinking in alginate scaffold for drug delivery and tissue engineering: A review

The actual tendency exhibits continuous increment to use alginate polysaccharides in drug delivery and tissue engineering fields due to its attractive properties. Alginate pH-sensitiveness and its fabrication techniques have been extensively reported in the literature. However, in this review, the essential role of crosslinking process in the scaffold design will be highlighted. We discuss the possibility to use a different type of crosslinking to create proper biomimetic alginate hydrogels, emphasizing the possibility to improve alginate mechanical properties through chemical modification by covalent crosslinking or ionic combination with other polymeric materials. At the same time, the relevance of the degradation process and biocompatibility in these applications is also detailed described.

Automated summary

The use of alginate polysaccharides in drug delivery and tissue engineering is on the rise due to their attractive properties. This review emphasizes the crucial role of crosslinking process in scaffold design, highlighting the potential to create biomimetic alginate hydrogels through different types of crosslinking. The possibility to enhance alginate mechanical properties through chemical modification and the importance of degradation process and biocompatibility in these applications are also discussed in detail.