期刊
EUROPEAN POLYMER JOURNAL
卷 161, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2021.110834
关键词
Supercritical CO2 foaming; Nanofibres; 3D reticular pore structure; Porous scaffolds; Endothelial cell migration; Vascular patches
资金
- National Center for International Research of Micro-Nano Molding Technology of Zhengzhou University in China
- National Natural Science Foundation of China [11372287, U1909219]
- Henan Province Science and Technology Research Project [172102410061]
The novel three-dimensional porous scaffolds, prepared using supercritical CO2 foaming technology with heterogeneous nanofibers, exhibited obvious nanofiber structures and 3D reticular pore structures. The scaffolds showed good mechanical properties and hydrophilicity, and were found to be biocompatible with human umbilical endothelial cells, promoting their adhesion, migration, and permeability. These 3D porous scaffolds have great potential for application in vascular patches.
As an artificial extracellular matrix, tissue engineering scaffolds promote tissue regeneration and repair. Therefore, the scaffold's internal structure is crucial for cell adhesion, growth, and migration. In this paper, based on the supercritical CO2 foaming technology, a novel three-dimensional (3D) porous polycaprolactone/polylactic acid tissue engineering scaffold induced by heterogeneous nanofibres was prepared by introducing the second phase of polylactic acid electrospinning nanofibres. The scanning electron microscopy results showed that the prepared scaffolds exhibited obvious nanofibre structures and 3D reticular pore structures. The influence of foaming temperature on pore morphology was also systematically explored. Tensile tests and water contact angle tests showed that the novel scaffolds exhibited good mechanical properties and hydrophilicity. The results of cross-sectional human umbilical endothelial cell (HUVEC) culture showed that the scaffolds were biocompatible and significantly promote the adhesion, migration and permeability of HUVECs. Single-cell migration assays showed that the 3D porous scaffolds effectively promote HUVEC migration. Therefore, 3D porous scaffolds have enormous application potential in the field of vascular patches.
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