期刊
EUROPEAN NEUROLOGY
卷 85, 期 1, 页码 31-38出版社
KARGER
DOI: 10.1159/000518211
关键词
Meta-analysis; Poststroke dysphagia; Repetitive transcranial magnetic stimulation; Transcranial direct current stimulation
资金
- National Natural Science Foundation of China [81901108, 82001125]
- Natural Science Foundation of Jiangsu Province [BK20180201]
- Foundation for Jiangsu Entrepreneurship and Innovation Doctors
The meta-analysis showed that both rTMS and tDCS are effective in improving swallowing function in poststroke dysphagia patients. However, more large-scale, blinded randomized controlled trials are needed to further investigate the effects of these therapies.
Background: Past research has indicated that repetitive transcranial magnetic stimulation (rTMS) on the pharyngeal motor cortex may be beneficial to poststroke dysphagic patients. In addition, some studies have supported that transcranial direct current stimulation (tDCS) over the pharyngeal motor cortex can improve swallowing function in poststroke dysphagia. However, some studies showed that rTMS and tDCS show no effect on poststroke dysphagia. This study aims to make a meta-analysis to investigate the therapy effect of rTMS and tDCS on poststroke dysphagia in randomized controlled trials (RCTs). Methods: We searched for studies published before March 2021 in databases (PubMed, Web of Science, MEDLINE, EMBASE, and Google Scholar). Meta-analysis was made to compute the results of included studies using STATA 12.0 software. Results: The present study shows a significant increase in the swallowing function in poststroke dysphagia given rTMS compared to those given sham rTMS (standardized mean difference [SMD] = 1.08, 95% confidence interval [CI] = 0.37-1.80, I-2 = 81.2%, p < 0.001). In addition, the study shows a significant increase in the swallowing function in poststroke dysphagia given tDCS (combined or not combined with conventional swallowing therapy), compared to those given sham tDCS (combined or not combined with conventional swallowing therapy) (SMD = 1.43, 95% CI = 0.73-2.13, I-2 = 77.6%, p < 0.001). Conclusions: The study demonstrates that rTMS and tDCS over the pharyngeal motor cortex show therapy effects on poststroke dysphagia. Many more large-scale, blinded RCTs are essential to investigate the effect of rTMS and tDCS on poststroke dysphagia.
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