An overview of the production methods for core-shell microspheres for parenteral controlled drug delivery

Core-shell microspheres hold great promise as a drug delivery system because they offer several benefits over monolithic microspheres in terms of release kinetics, for instance a reduced initial burst release, the possibility of delayed (pulsatile) release, and the possibility of dual-drug release. Also, the encapsulation efficiency can significantly be improved. Various methods have proven to be successful in producing these core-shell micro spheres, both the conventional bulk emulsion solvent evaporation method and methods in which the micro spheres are produced drop by drop. The latter have become increasingly popular because they provide improved control over the particle characteristics. This review assesses various production methods for core-shell microspheres and summarizes the characteristics of formulations prepared by the different methods, with a focus on their release kinetics.

Automated summary

Core-shell microspheres show promise as a drug delivery system due to their advantages over monolithic microspheres in terms of release kinetics, such as reduced initial burst release, delayed release, and dual-drug release. Various successful methods for producing these core-shell microspheres have been identified, with a focus on improving drug release efficiency through better control over particle characteristics.