Synthesis of Symmetrical Thiosulfonates via Cu(OTf)2-Catalyzed Reductive Homocoupling of Arenesulfonyl Chlorides

A variety of symmetrical thiosulfonates are synthesized via Cu-catalyzed reductive homocoupling of aryl sulfonyl chlorides. This protocol uses organic amine acting as a mild reductant and low-cost copper as an effective catalyst. Such a reductive coupling process features a broad substrate scope and good functional group tolerance. Related thiosulfonate products can also be converted into diverse functional molecules.

Automated summary

A variety of symmetrical thiosulfonates are synthesized through Cu-catalyzed reductive homocoupling of aryl sulfonyl chlorides, using organic amine as a mild reductant and low-cost copper as an effective catalyst. This method features a broad substrate scope and good functional group tolerance, with the thiosulfonate products being able to be converted into diverse functional molecules.