期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2021, 期 44, 页码 5914-5921出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.202101242
关键词
C-H activation; Eosin Y; Ethers; Glycine derivatives; Photocatalysis
资金
- National Natural Science Foundation of China [21772091]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
This work presents a visible-light-induced oxidative alpha-alkylation of glycine derivatives with ethers using Eosin Y as a catalyst. The reaction, conducted under blue light from a 3 W LED, produces a range of alpha-etherized glycine derivatives with good to excellent yields and functional group tolerance when tert-butyl hydroperoxide is used as the oxidant at ambient temperature. This operationally easy procedure offers an economical, metal-free, and mild approach for synthesizing alpha-etherized glycine derivatives.
In this work, a visible-light-induced oxidative alpha-alkylation of glycine derivatives with ethers has been developed in the presence of catalytic Eosin Y. Under the blue light of a 3 W LED, a range of alpha-etherized glycine derivatives, including alpha-amino esters, alpha-amino ketones and alpha-amino amides, were achieved with good to excellent yields and functional group tolerance with tert-butyl hydroperoxide (TBHP) as oxidant at ambient temperature. The operationally easy procedure provides an economical, metal-free, and mild alternative for the synthesis of the alpha-etherized glycine derivatives.
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