期刊
EUROPEAN JOURNAL OF ONCOLOGY NURSING
卷 57, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejon.2022.102099
关键词
Meta-analysis; Longitudinal cohort studies; Cognitive impairment; Cognitive function; Oncology; Nursing; Chemotherapy; Effect sizes
资金
- Basic Science Research Program through the Na-tional Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [2021R1A2C1094740]
- National Research Foundation of Korea [2021R1A2C1094740] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
This study found that breast cancer patients experienced worsened subjective cognitive impairment after starting chemotherapy compared to both non-chemotherapy patients and healthy controls. The impact of chemotherapy on cognitive impairment was shown to be acute rather than chronic, with the most significant effects occurring within the first month post chemotherapy.
Purpose: This meta-analysis with longitudinal prospective cohort studies aimed to (a) determine whether chemotherapy is associated with time-dependent subjective cognitive impairment outcomes in breast cancer patients, and (b) identify the time point with the highest impact of chemotherapy on subjective cognitive impairment. Methods: Data were gathered from PubMed, EMBASE, CINAHL, PsycInfo, and the Cochrane Library. The mean differences of the subjective cognitive impairment level between the chemotherapy-treated patients and controls (patients not treated by chemotherapy and healthy subjects) were calculated using effect sizes (Hedges' g) by clinical time periods. The five clinical time periods were (a) baseline, (b) during chemotherapy, (c) within 1 month postchemotherapy, (d) within 1 year postchemotherapy, and (e) 1 year or longer postchemotherapy. Results: Longitudinal data from nine data sets from 13 studies were pooled and analyzed. At baseline, chemotherapy-treated patients showed slightly better subjective cognitive impairment compared to patients not treated by chemotherapy and did not differ from healthy controls. Yet, the chemotherapy-treated patients had significantly worse subjective cognitive impairment compared to both type of controls after initiating chemotherapy. The effect sizes for the group differences were larger for the group comparison with healthy controls than the nonchemotherapy control (-0.50 vs.-0.19). The largest effects were found within 1 month post chemotherapy (-0.85), suggesting the acute impact of chemotherapy. Conclusions: Chemotherapy is associated with subjective cognitive impairment. The impact of chemotherapy appears to be an acute rather than a chronic side effect. Clinicians must consider including the assessment and management of subjective cognitive impairment in their routine practice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据