期刊
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
卷 266, 期 -, 页码 157-162出版社
ELSEVIER
DOI: 10.1016/j.ejogrb.2021.10.006
关键词
Pre-eclampsia; sFLT-1/PLGF; Cost-effectiveness; Hospitalization; Pregnancy
The study evaluated the implementation of PLGF-based testing at United Lincolnshire Trust Hospitals, showing a significant decrease in admission rates post-implementation for low-risk group and increased staff adherence to the sFLT-1/PLGF protocol. The high-risk group demonstrated shorter time from test to delivery, earlier gestational age at delivery, and lower birth weight.
Objectives: As a part of NHS' Innovation and Technology Payment programme (ITP), pregnant women were offered Placental Growth Factor (PLGF)-based testing to help rule out pre-eclampsia (PET) - a serious condition that affects approximately 2.3% of the female population. The study was aimed to evaluate the implementation of PLGF-based testing at United Lincolnshire Trust Hospitals (ULHT). Study Design: The soluble FMS like Tyrosine kinase 1/placental growth factor (sFlt-1/PLGF) ratio test was launched at ULHT on 8th October 2020. The project involved a review of an electronic maternity database (MEDWAY) for all women who had sFLT-1/PLGF ratio test performed at ULHT over a 5-month period (October 2020-February 2021). The sFlt-1/PLGF ratio was recorded alongside clinical outcome. Women were classified as low, moderate, and high risk for development of PET if the sFlt-1/PLGF ratio was <= 38, 39-84 and >= 85 respectively. Reasons for admission were further investigated and adherence to the sFLT-1/PLGF protocol was monitored to evaluate staff performance. Data was then statistically analysed with chi(2) and T-test for categorical and continuous variables respectively. Finally, sensitivity and specificity of the sFLT-1/PLGF was assessed with an ROC curve. Results: A total of 236 women had sFlt-1/PLGF ratio test performed in a five-month period. A two-time point analysis (a during implementation and post implementation phase) showed a significant decrease in the admission rates in the post-implementation phase in low-risk group (28.5% during imple-mentation vs 11.3% post-implementation, P < 0.05). Further analysis showed greater staff adherence to the sFLT-1/PLGF protocol in the post-implementation period. The high-risk group demonstrated shorter time from test to delivery, earlier gestational age at delivery and lower birth weight (P < 0.05). Conclusions: The study outcomes resulted in a successful submission of a business case. Successful triage of low-risk women at the point where historically admissions were considered reduced clinical workload and enabled better utilisation of resources by allowing focussed care on high-risk women for an optimal maternal and perinatal outcome. (C) 2021 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据