4.7 Article

Design, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Chemistry, Medicinal

Research progress of dual inhibitors targeting crosstalk between histone epigenetic modulators for cancer therapy

Ying-Chao Duan et al.

Summary: Abnormal epigenetics is a critical feature of human cancers, and targeting histone epigenetic modulators for anticancer drug discovery has made advances. However, challenges such as limited therapeutic profile, drug resistance, narrow safety margin, and toxicities exist. Co-targeting histone epigenetic modulators with different mechanisms has emerged as an effective strategy to overcome limitations.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Review Oncology

Anticancer Therapy with HDAC Inhibitors: Mechanism-Based Combination Strategies and Future Perspectives

Robert Jenke et al.

Summary: Epigenetic changes can drive cancer malignancy, while histone deacetylase inhibitors (HDACis) hold promise as anticancer drugs due to their ability to target multiple pathways relevant to the disease.

CANCERS (2021)

Review Oncology

Hepatocellular Carcinoma: An Overview of the Changing Landscape of Treatment Options

Andreas Koulouris et al.

Summary: In recent years, there has been significant progress in understanding predisposing factors and improving treatment options for hepatocellular carcinoma (HCC). Traditional chemotherapy has been replaced by targeted therapies like TKIs and immunotherapies as the standard of care for HCC patients. Newer agents such as atezolizumab plus bevacizumab for first-line treatment and novel anti-angiogenic factors for second-line treatment are showing promising results in clinical trials.

JOURNAL OF HEPATOCELLULAR CARCINOMA (2021)

Review Biochemistry & Molecular Biology

Two-hit wonders: The expanding universe of multitargeting epigenetic agents

Angel R. de Lera et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2020)

Article Chemistry, Medicinal

Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight

Terence C. S. Ho et al.

JOURNAL OF MEDICINAL CHEMISTRY (2020)

Article Chemistry, Medicinal

Design, synthesis and bioevaluation of novel substituted triazines as potential dual PI3K/mTOR inhibitors

Ting-Ting Wu et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Research progress of mTOR inhibitors

Yifan Chen et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

Review Chemistry, Medicinal

Histone deacetylase 8 (HDAC8) and its inhibitors with selectivity to other isoforms: An overview

Suvankar Banerjee et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2019)

Article Chemistry, Medicinal

HybridMolDB: A Manually Curated Database Dedicated to Hybrid Molecules for Chemical Biology and Drug Discovery

Yecheng Li et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)

Article Chemistry, Medicinal

Hit Dexter 2.0: Machine-Learning Models for the Prediction of Frequent Hitters

Conrad Stork et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)

Review Gastroenterology & Hepatology

Unmasking the pathological and therapeutic potential of histone deacetylases for liver cancer

Jun Zhao et al.

EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY (2019)

Review Chemistry, Multidisciplinary

Next-generation of selective histone deacetylase inhibitors

Feifei Yang et al.

RSC ADVANCES (2019)

Review Medicine, Research & Experimental

Histone Deacetylases and Histone Deacetylase Inhibitors: Molecular Mechanisms of Action in Various Cancers

Masumeh Sanaei et al.

ADVANCED BIOMEDICAL RESEARCH (2019)

Article Oncology

Histone deacetylase inhibitors in hepatocellular carcinoma: A therapeutic perspective

Diamantis Tsilimigras et al.

SURGICAL ONCOLOGY-OXFORD (2018)

Review Pharmacology & Pharmacy

Discovery and Development of ATP-Competitive mTOR Inhibitors Using Computational Approaches

Yao Luo et al.

CURRENT PHARMACEUTICAL DESIGN (2017)

Article Biochemistry & Molecular Biology

eCF309: a potent, selective and cell-permeable mTOR inhibitor

Craig Fraser et al.

MEDCHEMCOMM (2016)

Article Pharmacology & Pharmacy

Molecular Targeted Therapy for Hepatocellular Carcinoma: Present Status and Future Directions

Kyung-Ju Choi et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2015)

Review Gastroenterology & Hepatology

Hepatocellular carcinoma: From diagnosis to treatment

Abhijeet Waghray et al.

WORLD JOURNAL OF HEPATOLOGY (2015)

Article Oncology

Understanding, recognizing, and managing toxicities of targeted anticancer therapies

Grace K. Dy et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2013)

Article Gastroenterology & Hepatology

The Up-Regulation of Histone Deacetylase 8 Promotes Proliferation and Inhibits Apoptosis in Hepatocellular Carcinoma

Jian Wu et al.

DIGESTIVE DISEASES AND SCIENCES (2013)

Article Medicine, Research & Experimental

Anticancer effects of sodium butyrate on hepatocellular carcinoma cells in vitro

Hong-Gang Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Article Biochemistry & Molecular Biology

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

Benjamin E. L. Lauffer et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Multidisciplinary Sciences

mTOR kinase structure, mechanism and regulation

Haijuan Yang et al.

NATURE (2013)

Article Multidisciplinary Sciences

The translational landscape of mTOR signalling steers cancer initiation and metastasis

Andrew C. Hsieh et al.

NATURE (2012)

Article Gastroenterology & Hepatology

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

Augusto Villanueva et al.

GASTROENTEROLOGY (2008)

Article Biochemistry & Molecular Biology

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

Beth Apsel et al.

NATURE CHEMICAL BIOLOGY (2008)

Article Oncology

mTOR and cancer: insights into a complex relationship

David M. Sabatini

NATURE REVIEWS CANCER (2006)