4.7 Article

The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Geriatrics & Gerontology

The Impact of Disease Comorbidities in Alzheimer's Disease

Jose A. Santiago et al.

Summary: Alzheimer's disease (AD) is often accompanied by a variety of other chronic diseases, including diabetes and cardiovascular disease, which may increase the risk of AD. Research suggests that disruption in several shared biological pathways could be the underlying mechanism for the association between AD and these comorbidities. Inflammation is considered a common dysregulated pathway shared by most comorbidities associated with AD.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Chemistry, Medicinal

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer's Disease

Michele Rossi et al.

Summary: Alzheimer's disease's multifactorial nature hinders effective drug development. A research team developed sustainable multi-target-directed ligands based on inexpensive cashew nutshell liquid, selecting compounds through cell toxicity and enzymatic studies to confirm their activity.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

Review Clinical Neurology

Depression in Dementia or Dementia in Depression? Systematic Review of Studies and Hypotheses

Agnieszka Brzezinska et al.

CURRENT ALZHEIMER RESEARCH (2020)

Article Clinical Neurology

2020 Alzheimer's disease facts and figures

[Anonymous]

ALZHEIMERS & DEMENTIA (2020)

Review Biochemistry & Molecular Biology

Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Justin M. Long et al.

Article Clinical Neurology

Alzheimer's disease drug development pipeline: 2019

Jeffrey Cummings et al.

ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS (2019)

Article Geriatrics & Gerontology

Donepezil Treatment in Patients With Depression and Cognitive Impairment on Stable Antidepressant Treatment: A Randomized Controlled Trial

Davangere P. Devanand et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2018)

Review Chemistry, Medicinal

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Qi Li et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Neurosciences

The role of 5-HT receptors in depression

Christine N. Yohn et al.

MOLECULAR BRAIN (2017)

Review Pharmacology & Pharmacy

Multi-target therapeutics for neuropsychiatric and neurodegenerative disorders

Priya Bawa et al.

DRUG DISCOVERY TODAY (2016)

Review Clinical Neurology

The 5-HT1A receptor in Major Depressive Disorder

Joshua Kaufman et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2016)

Article Clinical Neurology

The prevalence of neuropsychiatric symptoms in Alzheimer's disease: Systematic review and meta-analysis

Qing-Fei Zhao et al.

JOURNAL OF AFFECTIVE DISORDERS (2016)

Article Chemistry, Medicinal

Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents

Xiaokang Li et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Multidisciplinary Sciences

Alzheimer's Disease associated with Psychiatric Comorbidities

Michelle L. Garcez et al.

ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS (2015)

Article Clinical Neurology

The Prevalence of Depression in Alzheimer's Disease: A Systematic Review and Meta-Analysis

Song Chi et al.

CURRENT ALZHEIMER RESEARCH (2015)

Article Geriatrics & Gerontology

Depression associated with dementia

H. Gutzmann et al.

ZEITSCHRIFT FUR GERONTOLOGIE UND GERIATRIE (2015)

Review Biotechnology & Applied Microbiology

Behavioral and Psychological Symptoms in Alzheimer's Disease

Xiao-Ling Li et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Clinical Neurology

Behavioral and Psychological Symptoms of Dementia

J. Cerejeira et al.

Frontiers in Neurology (2012)

Review Clinical Neurology

Depression and risk of developing dementia

Amy L. Byers et al.

NATURE REVIEWS NEUROLOGY (2011)

Review Cell Biology

5-HT1A receptor-regulated signal transduction pathways in brain

Abigail M. Polter et al.

CELLULAR SIGNALLING (2010)

Review Behavioral Sciences

The validity of scopolamine as a pharmacological model for cognitive impairment: A review of animal behavioral studies

Inge Klinkenberg et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2010)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Alzheimer's Disease

Henry W. Querfurth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Editorial Material Pharmacology & Pharmacy

Vilazodone, a novel dual-acting serotonergic antidepressant for managing major depression

Arif Khan

EXPERT OPINION ON INVESTIGATIONAL DRUGS (2009)

Review Neurosciences

5-HT1A receptor function in major depressive disorder

Jonathan Savitz et al.

PROGRESS IN NEUROBIOLOGY (2009)

Review Chemistry, Multidisciplinary

Serotonin receptors

David E. Nichols et al.

CHEMICAL REVIEWS (2008)

Review Chemistry, Medicinal

Multi-target-directed ligands to combat neurodegenerative diseases

Andrea Cavalli et al.

JOURNAL OF MEDICINAL CHEMISTRY (2008)

Review Pharmacology & Pharmacy

Targeting acetylcholinesterase to treat neurodegeneration

Ulrike Holzgrabe et al.

EXPERT OPINION ON THERAPEUTIC TARGETS (2007)

Review Multidisciplinary Sciences

A century of Alzheimer's disease

Michel Goedert et al.

SCIENCE (2006)

Article Chemistry, Medicinal

Indolebutylamines as selective 5-HT1A agonists

T Heinrich et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)

Article Chemistry, Medicinal

High throughput artificial membrane permeability assay for blood-brain barrier

L Di et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2003)

Review Clinical Neurology

Role of selective serotonin reuptake inhibitors in psychiatric disorders: a comprehensive review

M Vaswani et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2003)

Review Physiology

Alzheimer's disease: Genes, proteins, and therapy

DJ Selkoe

PHYSIOLOGICAL REVIEWS (2001)

Review Medicine, General & Internal

Role of serotonin in memory impairment

HC Buhot et al.

ANNALS OF MEDICINE (2000)